Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

Alan C. Foster; Annamakia Vezzani; Edward D. French; Robert Schwarcz

doi:10.1016/0304-3940(84)90050-8

Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

Alan C. Foster, Annamakia Vezzani, Edward D. French, Robert Schwarcz

Research output: Contribution to journal › Article › peer-review

391 Scopus citations

Abstract

Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN). In the rat striatum, KYNA blocked the neurotoxic effects of QUIN in preference to those of other excitotoxins. In the hippocampus, KYNA antagonized both the neurodegeneration and seizures caused by the local application of QUIN. These properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders.

Original language	English (US)
Pages (from-to)	273-278
Number of pages	6
Journal	Neuroscience Letters
Volume	48
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(84)90050-8
State	Published - Aug 10 1984
Externally published	Yes

Keywords

Huntington's disease
epilepsy
ibotenic acid
kainic acid
kynurenic acid
neurotoxicity
quinolinic acid
seizures

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(84)90050-8

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title = "Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid",

abstract = "Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN). In the rat striatum, KYNA blocked the neurotoxic effects of QUIN in preference to those of other excitotoxins. In the hippocampus, KYNA antagonized both the neurodegeneration and seizures caused by the local application of QUIN. These properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders.",

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T1 - Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

AU - Foster, Alan C.

AU - Vezzani, Annamakia

AU - French, Edward D.

AU - Schwarcz, Robert

PY - 1984/8/10

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AB - Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN). In the rat striatum, KYNA blocked the neurotoxic effects of QUIN in preference to those of other excitotoxins. In the hippocampus, KYNA antagonized both the neurodegeneration and seizures caused by the local application of QUIN. These properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders.

KW - Huntington's disease

KW - epilepsy

KW - ibotenic acid

KW - kainic acid

KW - kynurenic acid

KW - neurotoxicity

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KW - seizures

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Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

Abstract

Keywords

ASJC Scopus subject areas

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