Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena.

N. I. Larionova; I. P. Gladysheva; I. N. Topchieva; N. F. Kazanskaia

Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena.

Translated title of the contribution: Conjugation of classic Bowman-Birk soy inhibitor with a copolymer of ethylene oxide and propylene oxide

N. I. Larionova, I. P. Gladysheva, I. N. Topchieva, N. F. Kazanskaia

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A classical soybean inhibitor of the Bowman-Birk type (BBI) with a copolymer of ethylene oxide and propylene oxide (PE) has been synthesized. The BBI-PE conjugate contain five covalently bound polymeric chains per one protein molecule and retains its capacity to inhibit trypsin (Ki = 10(-10) M), alpha-chymotrypsin (Ki = 7 x 10(-8) M) and human granulocyte elastase (Ki = 3 x 10(-8) M). The preservation of the antiproteinase activity in the antichymotrypsin center creates a prerequisite for the manifestation of the anticarcinogenic effect of the inhibitor.

Translated title of the contribution	Conjugation of classic Bowman-Birk soy inhibitor with a copolymer of ethylene oxide and propylene oxide
Original language	Russian
Pages (from-to)	1658-1664
Number of pages	7
Journal	Biokhimiya
Volume	58
Issue number	10
State	Published - Oct 1993
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

Cite this

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title = "Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi {\'e}tilena i okisi propilena.",

abstract = "A classical soybean inhibitor of the Bowman-Birk type (BBI) with a copolymer of ethylene oxide and propylene oxide (PE) has been synthesized. The BBI-PE conjugate contain five covalently bound polymeric chains per one protein molecule and retains its capacity to inhibit trypsin (Ki = 10(-10) M), alpha-chymotrypsin (Ki = 7 x 10(-8) M) and human granulocyte elastase (Ki = 3 x 10(-8) M). The preservation of the antiproteinase activity in the antichymotrypsin center creates a prerequisite for the manifestation of the anticarcinogenic effect of the inhibitor.",

author = "Larionova, {N. I.} and Gladysheva, {I. P.} and Topchieva, {I. N.} and Kazanskaia, {N. F.}",

year = "1993",

month = oct,

language = "Russian",

volume = "58",

pages = "1658--1664",

journal = "Biokhimiia (Moscow, Russia)",

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T1 - Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena.

AU - Larionova, N. I.

AU - Gladysheva, I. P.

AU - Topchieva, I. N.

AU - Kazanskaia, N. F.

PY - 1993/10

Y1 - 1993/10

N2 - A classical soybean inhibitor of the Bowman-Birk type (BBI) with a copolymer of ethylene oxide and propylene oxide (PE) has been synthesized. The BBI-PE conjugate contain five covalently bound polymeric chains per one protein molecule and retains its capacity to inhibit trypsin (Ki = 10(-10) M), alpha-chymotrypsin (Ki = 7 x 10(-8) M) and human granulocyte elastase (Ki = 3 x 10(-8) M). The preservation of the antiproteinase activity in the antichymotrypsin center creates a prerequisite for the manifestation of the anticarcinogenic effect of the inhibitor.

AB - A classical soybean inhibitor of the Bowman-Birk type (BBI) with a copolymer of ethylene oxide and propylene oxide (PE) has been synthesized. The BBI-PE conjugate contain five covalently bound polymeric chains per one protein molecule and retains its capacity to inhibit trypsin (Ki = 10(-10) M), alpha-chymotrypsin (Ki = 7 x 10(-8) M) and human granulocyte elastase (Ki = 3 x 10(-8) M). The preservation of the antiproteinase activity in the antichymotrypsin center creates a prerequisite for the manifestation of the anticarcinogenic effect of the inhibitor.

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AN - SCOPUS:0027675184

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JO - Biokhimiia (Moscow, Russia)

JF - Biokhimiia (Moscow, Russia)

IS - 10

ER -

Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena.

Abstract

ASJC Scopus subject areas

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