Kinetics of the digoxin-aspirin combination

Paul E. Fenster; Keith A. Comess; Christine Dahl Hanson; Paul R. Finley

doi:10.1038/clpt.1982.184

Kinetics of the digoxin-aspirin combination

Paul E. Fenster, Keith A. Comess, Christine Dahl Hanson, Paul R. Finley

Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Digoxin interacts kinetically with many drugs in man. These interactions may result in digoxin toxicity. Aspirin has been shown to raise serum digoxin levels in the dog. We evaluated the effect of aspirin on digoxin single-dose kinetics in eight healthy adults. Aspirin induced no change in digoxin total body clearance, volume of distribution, elimination half-life, or renal or creatinine clearance. Trough serum salicylate levels ranged from 93 to 163 μg/ml. We conclude that no alteration is required in digoxin dosing when aspirin is used.

Original language	English (US)
Pages (from-to)	428-430
Number of pages	3
Journal	Clinical Pharmacology and Therapeutics
Volume	32
Issue number	4
DOIs	https://doi.org/10.1038/clpt.1982.184
State	Published - Oct 1982

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1038/clpt.1982.184

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AU - Hanson, Christine Dahl

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AB - Digoxin interacts kinetically with many drugs in man. These interactions may result in digoxin toxicity. Aspirin has been shown to raise serum digoxin levels in the dog. We evaluated the effect of aspirin on digoxin single-dose kinetics in eight healthy adults. Aspirin induced no change in digoxin total body clearance, volume of distribution, elimination half-life, or renal or creatinine clearance. Trough serum salicylate levels ranged from 93 to 163 μg/ml. We conclude that no alteration is required in digoxin dosing when aspirin is used.

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Kinetics of the digoxin-aspirin combination

Abstract

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