Kinetic studies of β-sheet protein folding

Andrew P. Capaldi; Sheena E. Radford

doi:10.1016/S0959-440X(98)80014-6

Kinetic studies of β-sheet protein folding

Andrew P. Capaldi, Sheena E. Radford

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

New studies have shown that folding of β-sheet proteins can occur with and without intermediates, with fast to slow refolding rates and late to very late transition states. These experiments demonstrate that, despite early speculation to the contrary, β-sheet protein folding does not appear to be fundamentally different from that of helical and mixed α,β proteins.

Original language	English (US)
Pages (from-to)	86-92
Number of pages	7
Journal	Current Opinion in Structural Biology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/S0959-440X(98)80014-6
State	Published - Feb 1998
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/S0959-440X(98)80014-6

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title = "Kinetic studies of β-sheet protein folding",

abstract = "New studies have shown that folding of β-sheet proteins can occur with and without intermediates, with fast to slow refolding rates and late to very late transition states. These experiments demonstrate that, despite early speculation to the contrary, β-sheet protein folding does not appear to be fundamentally different from that of helical and mixed α,β proteins.",

author = "Capaldi, {Andrew P.} and Radford, {Sheena E.}",

note = "Funding Information: We are indebted to Kevin'Plaxco, lfiaki Guijarro, Lila Gierasch, Jane Clarke and Tony Clarke for sending us preprinrs of their work, much of which is described in this review. We are also grateful to Alan I\erry for making the figure and Smarr Ferguson, John Reader and Neil Ferguson for helpful discussions. We thank members of the Radford and Berry Groups for critically reading this review. We acknowledge the Wellcome Trust and the BBSRC for financial support.",

year = "1998",

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doi = "10.1016/S0959-440X(98)80014-6",

language = "English (US)",

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journal = "Current Opinion in Structural Biology",

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AU - Capaldi, Andrew P.

AU - Radford, Sheena E.

N1 - Funding Information: We are indebted to Kevin'Plaxco, lfiaki Guijarro, Lila Gierasch, Jane Clarke and Tony Clarke for sending us preprinrs of their work, much of which is described in this review. We are also grateful to Alan I\erry for making the figure and Smarr Ferguson, John Reader and Neil Ferguson for helpful discussions. We thank members of the Radford and Berry Groups for critically reading this review. We acknowledge the Wellcome Trust and the BBSRC for financial support.

PY - 1998/2

Y1 - 1998/2

N2 - New studies have shown that folding of β-sheet proteins can occur with and without intermediates, with fast to slow refolding rates and late to very late transition states. These experiments demonstrate that, despite early speculation to the contrary, β-sheet protein folding does not appear to be fundamentally different from that of helical and mixed α,β proteins.

AB - New studies have shown that folding of β-sheet proteins can occur with and without intermediates, with fast to slow refolding rates and late to very late transition states. These experiments demonstrate that, despite early speculation to the contrary, β-sheet protein folding does not appear to be fundamentally different from that of helical and mixed α,β proteins.

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Kinetic studies of β-sheet protein folding

Abstract

ASJC Scopus subject areas

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