Kinetic evaluation of the propranoloi-quinidine combination

Paul Fenster; Donald Perrier; Michael Mayersohn; Frank I. Marcus

doi:10.1038/clpt.1980.62

Kinetic evaluation of the propranoloi-quinidine combination

Paul Fenster
, Donald Perrier
, Michael Mayersohn
, Frank I. Marcus

Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The kinetics of quinidine and propranolol, administered singly and in combination, were evaluated in 5 healthy subjects. The orally administered doses resulted in plasma concentrations within the therapeutic range. For each drug the average steady-state plasma concentration, maximal plasma concentration, and time of maximum plasma concentration were not altered by the presence of the other drug. This study shows no kinetic interaction between quinidine and propranolol in normal subjects.

Original language	English (US)
Pages (from-to)	450-453
Number of pages	4
Journal	Clinical Pharmacology and Therapeutics
Volume	27
Issue number	4
DOIs	https://doi.org/10.1038/clpt.1980.62
State	Published - Apr 1980

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1038/clpt.1980.62

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title = "Kinetic evaluation of the propranoloi-quinidine combination",

abstract = "The kinetics of quinidine and propranolol, administered singly and in combination, were evaluated in 5 healthy subjects. The orally administered doses resulted in plasma concentrations within the therapeutic range. For each drug the average steady-state plasma concentration, maximal plasma concentration, and time of maximum plasma concentration were not altered by the presence of the other drug. This study shows no kinetic interaction between quinidine and propranolol in normal subjects.",

author = "Paul Fenster and Donald Perrier and Michael Mayersohn and Marcus, \{Frank I.\}",

year = "1980",

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doi = "10.1038/clpt.1980.62",

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AU - Mayersohn, Michael

AU - Marcus, Frank I.

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N2 - The kinetics of quinidine and propranolol, administered singly and in combination, were evaluated in 5 healthy subjects. The orally administered doses resulted in plasma concentrations within the therapeutic range. For each drug the average steady-state plasma concentration, maximal plasma concentration, and time of maximum plasma concentration were not altered by the presence of the other drug. This study shows no kinetic interaction between quinidine and propranolol in normal subjects.

AB - The kinetics of quinidine and propranolol, administered singly and in combination, were evaluated in 5 healthy subjects. The orally administered doses resulted in plasma concentrations within the therapeutic range. For each drug the average steady-state plasma concentration, maximal plasma concentration, and time of maximum plasma concentration were not altered by the presence of the other drug. This study shows no kinetic interaction between quinidine and propranolol in normal subjects.

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UR - https://www.scopus.com/pages/publications/0018851912#tab=citedBy

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DO - 10.1038/clpt.1980.62

M3 - Article

C2 - 7357801

AN - SCOPUS:0018851912

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EP - 453

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

IS - 4

ER -

Kinetic evaluation of the propranoloi-quinidine combination

Abstract

ASJC Scopus subject areas

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