TY - JOUR
T1 - Kinetic evaluation of the propranoloi-quinidine combination
AU - Fenster, Paul
AU - Perrier, Donald
AU - Mayersohn, Michael
AU - Marcus, Frank I.
PY - 1980/4
Y1 - 1980/4
N2 - The kinetics of quinidine and propranolol, administered singly and in combination, were evaluated in 5 healthy subjects. The orally administered doses resulted in plasma concentrations within the therapeutic range. For each drug the average steady-state plasma concentration, maximal plasma concentration, and time of maximum plasma concentration were not altered by the presence of the other drug. This study shows no kinetic interaction between quinidine and propranolol in normal subjects.
AB - The kinetics of quinidine and propranolol, administered singly and in combination, were evaluated in 5 healthy subjects. The orally administered doses resulted in plasma concentrations within the therapeutic range. For each drug the average steady-state plasma concentration, maximal plasma concentration, and time of maximum plasma concentration were not altered by the presence of the other drug. This study shows no kinetic interaction between quinidine and propranolol in normal subjects.
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U2 - 10.1038/clpt.1980.62
DO - 10.1038/clpt.1980.62
M3 - Article
C2 - 7357801
AN - SCOPUS:0018851912
SN - 0009-9236
VL - 27
SP - 450
EP - 453
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
IS - 4
ER -