Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium

Bilal A. Naved, Joseph V. Bonventre, Jeffrey A. Hubbell, Neil A. Hukriede, Benjamin D. Humphreys, Carl Kesselman, M. Todd Valerius, Andrew P. McMahon, Stuart J. Shankland, Jason A. Wertheim, Michael J.V. White, Mark P. de Caestecker, Iain A. Drummond

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Acute kidney injury impacts ∼13.3 million individuals and causes ∼1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney injury, including cell cycle arrest, senescence, inflammation, mitochondrial dysfunction, and endothelial injury and dysfunction, and can lead to chronic inflammation and fibrosis. However, factors enabling productive repair versus nonproductive, persistent injury states remain less understood. The (Re)Building a Kidney (RBK) consortium is a National Institute of Diabetes and Digestive and Kidney Diseases consortium focused on both endogenous kidney repair mechanisms and the generation of new kidney tissue. This short review provides an update on RBK studies of endogenous nephron repair, addressing the following questions: (i) What is productive nephron repair? (ii) What are the cellular sources and drivers of repair? and (iii) How do RBK studies promote development of therapeutics? Also, we provide a guide to RBK's open access data hub for accessing, downloading, and further analyzing data sets.

Original languageEnglish (US)
Pages (from-to)845-853
Number of pages9
JournalKidney International
Volume101
Issue number5
DOIs
StatePublished - May 2022
Externally publishedYes

Keywords

  • acute kidney injury
  • cell signaling
  • fibrosis
  • glomerulus
  • inflammation
  • proximal tubule

ASJC Scopus subject areas

  • Nephrology

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