Kidney and lung in pathology: mechanisms and clinical implications

Ersilia Satta, Carmelo Alfarone, Alfonso de Maio, Sandro Gentile, Carmine Romano, Mario Polverino, Francesca Polverino

Research output: Contribution to journalReview articlepeer-review


There is a close, physiological, relationship between kidney and lung that begin in the fetal age, and is aimed to keep homeostatic balance in the body. From a pathological point of view, the kidneys could be damaged by inflammatory mediators or by immune-mediated factors linked to a primary lung disease or, conversely, it could be the kidney disease that causes lung damage. Non-immunological mechanisms are frequently involved in renal and pulmonary diseases, as observed in chronic conditions. This crosstalk have clinical and therapeutic consequences. This review aims to describe the pulmonary-renal link in physiology and in pathological conditions.

Original languageEnglish (US)
Article number819
JournalMultidisciplinary Respiratory Medicine
StatePublished - 2022


  • Acute kidney injury
  • Acute lung injury
  • Chemokines. us
  • Crosstalk

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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