Key advances in mechanisms of asthma, allergy, and immunology in 2009

Fred D. Finkelman; Joshua A. Boyce; Donata Vercelli; Marc E. Rothenberg

doi:10.1016/j.jaci.2009.12.936

Key advances in mechanisms of asthma, allergy, and immunology in 2009

Fred D. Finkelman, Joshua A. Boyce, Donata Vercelli, Marc E. Rothenberg

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The year 2009 was marked by rapid progress in understanding cellular and chemical mechanisms in the pathogenesis of asthma and other allergic disorders. Studies published in the Journal of Allergy and Clinical Immunology described advances in our knowledge of signaling molecules and pathways, cytokines, and activation and tolerance in asthma and murine models of this disease; food allergy; anaphylaxis and immediate hypersensitivity; mast cells and their disorders; atopic dermatitis; allergic conjunctivitis; nasal polyposis; and hypereosinophilic syndromes. Additional studies provided novel information about the induction and regulation of allergic inflammation and the genetic determinants of asthma and responsiveness to asthma therapy. Critical features of these studies and their potential effect on human atopic disorders are summarized here.

Original language	English (US)
Pages (from-to)	312-318
Number of pages	7
Journal	Journal of Allergy and Clinical Immunology
Volume	125
Issue number	2
DOIs	https://doi.org/10.1016/j.jaci.2009.12.936
State	Published - Feb 2010

Keywords

Allergic conjunctivitis
allergic inflammation
anaphylaxis
asthma
asthma genetics
atopic dermatitis
eosinophils
food allergy
immediate hypersensitivity
mast cells
nasal polyposis
polymorphisms

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.jaci.2009.12.936

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title = "Key advances in mechanisms of asthma, allergy, and immunology in 2009",

abstract = "The year 2009 was marked by rapid progress in understanding cellular and chemical mechanisms in the pathogenesis of asthma and other allergic disorders. Studies published in the Journal of Allergy and Clinical Immunology described advances in our knowledge of signaling molecules and pathways, cytokines, and activation and tolerance in asthma and murine models of this disease; food allergy; anaphylaxis and immediate hypersensitivity; mast cells and their disorders; atopic dermatitis; allergic conjunctivitis; nasal polyposis; and hypereosinophilic syndromes. Additional studies provided novel information about the induction and regulation of allergic inflammation and the genetic determinants of asthma and responsiveness to asthma therapy. Critical features of these studies and their potential effect on human atopic disorders are summarized here.",

keywords = "Allergic conjunctivitis, allergic inflammation, anaphylaxis, asthma, asthma genetics, atopic dermatitis, eosinophils, food allergy, immediate hypersensitivity, mast cells, nasal polyposis, polymorphisms",

author = "Finkelman, {Fred D.} and Boyce, {Joshua A.} and Donata Vercelli and Rothenberg, {Marc E.}",

note = "Funding Information: Disclosure of potential conflict of interest: F. D. Finkelman has received research support from Abbott Pharmaceuticals and is treasurer-elect for the Federation of American Societies for Experimental Biology. J. A. Boyce is a consultant for Merck. D. Vercelli has received research support from the National Institutes of Health and the Food Allergy and Anaphylaxis Network. M. E. Rothenberg is a speaker and consultant for Merck; is a consultant for Ception Therapeutics, Novartis, Nycomed, Centocor, BioCryst Pharmaceuticals, and Endo Pharmaceuticals; has received research support from the National Institutes of Health, the Food Allergy and Anaphylaxis Network, and the Dana Foundation; is on the Medical Advisory Board for the American Partnership for Eosinophilic Disorders; and is on the Executive Council for the International Eosinophil Society. ",

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Key advances in mechanisms of asthma, allergy, and immunology in 2009

Abstract

Keywords

ASJC Scopus subject areas

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