Keratin nanomaterial coating limits epithelial downgrowth around percutaneous devices

Brian T. Bennett, James Peter Beck, Kent N. Bachus, Alexis Trent, Mark Vandyke, Sujee Jeyapalina

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Percutaneous medical devices are increasingly common for therapeutic intervention in the treatment of complex and challenging pathologies. Despite the implementation of improved implant designs and skin-implant interface maintenance protocols, there remains no ideal strategy to resolve the mechanical and biochemical disintegration of the skin-implant interface. However, in live animal models, immediate mechanical capture of the skin at the skin-implant interface by porous coated titanium implant surfaces has been shown to decrease regression rates as compared to smooth surfaces. It is believed that the addition of a biomimetic coating that resembles the nail plate (i.e., keratin nanomaterials) could provide biochemically-mediated surfaces for enhancing epidermal cell adhesion, and hence, preventing downgrowth. It was therefore hypothesized that keratin nanomaterial coatings with optimized crystallinity could result in the formation of a physiologically stable, infection-free, non-migratory, skin-to-device interface.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages429
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Externally publishedYes
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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