Jekyll and Hyde: Activating the Hypoxic Translational Machinery

J. J.David Ho; Jonathan H. Schatz; Jim Uniacke; Stephen Lee

doi:10.1016/j.tibs.2020.11.006

Jekyll and Hyde: Activating the Hypoxic Translational Machinery

J. J.David Ho, Jonathan H. Schatz, Jim Uniacke, Stephen Lee

Medicine

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

Global translational remodeling has emerged as a principal mechanism of biological adaptation. Oxygen deficiency (hypoxia) disables the basal protein synthesis machinery (‘Jekyll’) and activates a hypoxic translational architecture (‘Hyde’) to drive translatome remodeling. Independent from mRNA-level fluctuations, this newer paradigm modernizes a field traditionally dominated by the hypoxia-inducible factor (HIF) transcriptional program.

Original language	English (US)
Pages (from-to)	171-174
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.tibs.2020.11.006
State	Published - Mar 2021

Keywords

HIF
hypoxia
oxygen
protein synthesis
translation heterogeneity
translatome

ASJC Scopus subject areas

Biochemistry
Molecular Biology

Access to Document

10.1016/j.tibs.2020.11.006

Cite this

@article{af6955e502c1478dbedbbdc00ece94a8,

title = "Jekyll and Hyde: Activating the Hypoxic Translational Machinery",

abstract = "Global translational remodeling has emerged as a principal mechanism of biological adaptation. Oxygen deficiency (hypoxia) disables the basal protein synthesis machinery ({\textquoteleft}Jekyll{\textquoteright}) and activates a hypoxic translational architecture ({\textquoteleft}Hyde{\textquoteright}) to drive translatome remodeling. Independent from mRNA-level fluctuations, this newer paradigm modernizes a field traditionally dominated by the hypoxia-inducible factor (HIF) transcriptional program.",

keywords = "HIF, hypoxia, oxygen, protein synthesis, translation heterogeneity, translatome",

author = "Ho, {J. J.David} and Schatz, {Jonathan H.} and Jim Uniacke and Stephen Lee",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2021",

month = mar,

doi = "10.1016/j.tibs.2020.11.006",

language = "English (US)",

volume = "46",

pages = "171--174",

journal = "Trends in Biochemical Sciences",

issn = "0968-0004",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Jekyll and Hyde

T2 - Activating the Hypoxic Translational Machinery

AU - Ho, J. J.David

AU - Schatz, Jonathan H.

AU - Uniacke, Jim

AU - Lee, Stephen

PY - 2021/3

Y1 - 2021/3

N2 - Global translational remodeling has emerged as a principal mechanism of biological adaptation. Oxygen deficiency (hypoxia) disables the basal protein synthesis machinery (‘Jekyll’) and activates a hypoxic translational architecture (‘Hyde’) to drive translatome remodeling. Independent from mRNA-level fluctuations, this newer paradigm modernizes a field traditionally dominated by the hypoxia-inducible factor (HIF) transcriptional program.

AB - Global translational remodeling has emerged as a principal mechanism of biological adaptation. Oxygen deficiency (hypoxia) disables the basal protein synthesis machinery (‘Jekyll’) and activates a hypoxic translational architecture (‘Hyde’) to drive translatome remodeling. Independent from mRNA-level fluctuations, this newer paradigm modernizes a field traditionally dominated by the hypoxia-inducible factor (HIF) transcriptional program.

KW - HIF

KW - hypoxia

KW - oxygen

KW - protein synthesis

KW - translation heterogeneity

KW - translatome

UR - http://www.scopus.com/inward/record.url?scp=85097456928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85097456928&partnerID=8YFLogxK

U2 - 10.1016/j.tibs.2020.11.006

DO - 10.1016/j.tibs.2020.11.006

M3 - Short survey

C2 - 33309326

AN - SCOPUS:85097456928

SN - 0968-0004

VL - 46

SP - 171

EP - 174

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 3

ER -

Jekyll and Hyde: Activating the Hypoxic Translational Machinery

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this