Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma

Daruka Mahadevan; Gregory C. Rogers

doi:10.1016/j.trecan.2020.03.009

Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma

Daruka Mahadevan
, Gregory C. Rogers

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease. Here, we explore combinatorial therapeutic strategies for either preventing or eliminating DIT cells.

Original language	English (US)
Pages (from-to)	627-630
Number of pages	4
Journal	Trends in Cancer
Volume	6
Issue number	8
DOIs	https://doi.org/10.1016/j.trecan.2020.03.009
State	Published - Aug 2020

Keywords

aneuploidy
drug resistance
polyploidy
tetraploidy
tumor evolution

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2020.03.009

Cite this

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title = "Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma",

abstract = "Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease. Here, we explore combinatorial therapeutic strategies for either preventing or eliminating DIT cells.",

keywords = "aneuploidy, drug resistance, polyploidy, tetraploidy, tumor evolution",

author = "Daruka Mahadevan and Rogers, \{Gregory C.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = aug,

doi = "10.1016/j.trecan.2020.03.009",

language = "English (US)",

volume = "6",

pages = "627--630",

journal = "Trends in Cancer",

issn = "2405-8033",

publisher = "Cell Press",

number = "8",

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TY - JOUR

T1 - Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma

AU - Mahadevan, Daruka

AU - Rogers, Gregory C.

PY - 2020/8

Y1 - 2020/8

N2 - Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease. Here, we explore combinatorial therapeutic strategies for either preventing or eliminating DIT cells.

AB - Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease. Here, we explore combinatorial therapeutic strategies for either preventing or eliminating DIT cells.

KW - aneuploidy

KW - drug resistance

KW - polyploidy

KW - tetraploidy

KW - tumor evolution

UR - https://www.scopus.com/pages/publications/85083016987

UR - https://www.scopus.com/pages/publications/85083016987#tab=citedBy

U2 - 10.1016/j.trecan.2020.03.009

DO - 10.1016/j.trecan.2020.03.009

M3 - Short survey

C2 - 32291237

AN - SCOPUS:85083016987

SN - 2405-8033

VL - 6

SP - 627

EP - 630

JO - Trends in Cancer

JF - Trends in Cancer

IS - 8

ER -

Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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