Itraconazole treatment of experimental systemic candidiasis in Male rats

Michael L. Yozwiak; John N. Galgiani

doi:10.1080/02681218780000171

Itraconazole treatment of experimental systemic candidiasis in Male rats

Michael L. Yozwiak
, John N. Galgiani

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

After intravenous infection with Candida albicans, rats received daily doses of itraconazole for 3 days. All rats receiving 2·5 mg kg^-1 day^-1 survived while all rats receiving sham-treatment died. With subsequent reduction of the itraconazole dose to 0·63 mg kg^-1 day^-1, no survival occurred and mortality rates equalled those of the control group.

Original language	English (US)
Pages (from-to)	125-126
Number of pages	2
Journal	Medical mycology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1080/02681218780000171
State	Published - 1987

ASJC Scopus subject areas

Infectious Diseases

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10.1080/02681218780000171

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title = "Itraconazole treatment of experimental systemic candidiasis in Male rats",

abstract = "After intravenous infection with Candida albicans, rats received daily doses of itraconazole for 3 days. All rats receiving 2·5 mg kg-1 day-1 survived while all rats receiving sham-treatment died. With subsequent reduction of the itraconazole dose to 0·63 mg kg-1 day-1, no survival occurred and mortality rates equalled those of the control group.",

author = "Yozwiak, \{Michael L.\} and Galgiani, \{John N.\}",

note = "Funding Information: This work was supported in part by the Veterans Administration and Janssen Pharaceutica, Inc.",

year = "1987",

doi = "10.1080/02681218780000171",

language = "English (US)",

volume = "25",

pages = "125--126",

journal = "Medical mycology",

issn = "1369-3786",

publisher = "Oxford University Press",

number = "2",

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T1 - Itraconazole treatment of experimental systemic candidiasis in Male rats

AU - Yozwiak, Michael L.

AU - Galgiani, John N.

N1 - Funding Information: This work was supported in part by the Veterans Administration and Janssen Pharaceutica, Inc.

PY - 1987

Y1 - 1987

N2 - After intravenous infection with Candida albicans, rats received daily doses of itraconazole for 3 days. All rats receiving 2·5 mg kg-1 day-1 survived while all rats receiving sham-treatment died. With subsequent reduction of the itraconazole dose to 0·63 mg kg-1 day-1, no survival occurred and mortality rates equalled those of the control group.

AB - After intravenous infection with Candida albicans, rats received daily doses of itraconazole for 3 days. All rats receiving 2·5 mg kg-1 day-1 survived while all rats receiving sham-treatment died. With subsequent reduction of the itraconazole dose to 0·63 mg kg-1 day-1, no survival occurred and mortality rates equalled those of the control group.

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UR - https://www.scopus.com/pages/publications/0023264149#tab=citedBy

U2 - 10.1080/02681218780000171

DO - 10.1080/02681218780000171

M3 - Article

C2 - 3037058

AN - SCOPUS:0023264149

SN - 1369-3786

VL - 25

SP - 125

EP - 126

JO - Medical mycology

JF - Medical mycology

IS - 2

ER -

Itraconazole treatment of experimental systemic candidiasis in Male rats

Abstract

ASJC Scopus subject areas

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