After intravenous infection with Candida albicans, rats received daily doses of itraconazole for 3 days. All rats receiving 2·5 mg kg-1 day-1 survived while all rats receiving sham-treatment died. With subsequent reduction of the itraconazole dose to 0·63 mg kg-1 day-1, no survival occurred and mortality rates equalled those of the control group.
ASJC Scopus subject areas
- Infectious Diseases