Itraconazole treatment of experimental systemic candidiasis in Male rats

Michael L. Yozwiak; John N. Galgiani

doi:10.1080/02681218780000171

Itraconazole treatment of experimental systemic candidiasis in Male rats

Michael L. Yozwiak, John N. Galgiani

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

After intravenous infection with Candida albicans, rats received daily doses of itraconazole for 3 days. All rats receiving 2·5 mg kg^-1 day^-1 survived while all rats receiving sham-treatment died. With subsequent reduction of the itraconazole dose to 0·63 mg kg^-1 day^-1, no survival occurred and mortality rates equalled those of the control group.

Original language	English (US)
Pages (from-to)	125-126
Number of pages	2
Journal	Medical mycology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1080/02681218780000171
State	Published - 1987

ASJC Scopus subject areas

Infectious Diseases

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10.1080/02681218780000171

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title = "Itraconazole treatment of experimental systemic candidiasis in Male rats",

abstract = "After intravenous infection with Candida albicans, rats received daily doses of itraconazole for 3 days. All rats receiving 2·5 mg kg-1 day-1 survived while all rats receiving sham-treatment died. With subsequent reduction of the itraconazole dose to 0·63 mg kg-1 day-1, no survival occurred and mortality rates equalled those of the control group.",

author = "Yozwiak, {Michael L.} and Galgiani, {John N.}",

note = "Funding Information: This work was supported in part by the Veterans Administration and Janssen Pharaceutica, Inc.",

year = "1987",

doi = "10.1080/02681218780000171",

language = "English (US)",

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pages = "125--126",

journal = "Medical mycology",

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publisher = "Oxford University Press",

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T1 - Itraconazole treatment of experimental systemic candidiasis in Male rats

AU - Yozwiak, Michael L.

AU - Galgiani, John N.

N1 - Funding Information: This work was supported in part by the Veterans Administration and Janssen Pharaceutica, Inc.

PY - 1987

Y1 - 1987

N2 - After intravenous infection with Candida albicans, rats received daily doses of itraconazole for 3 days. All rats receiving 2·5 mg kg-1 day-1 survived while all rats receiving sham-treatment died. With subsequent reduction of the itraconazole dose to 0·63 mg kg-1 day-1, no survival occurred and mortality rates equalled those of the control group.

AB - After intravenous infection with Candida albicans, rats received daily doses of itraconazole for 3 days. All rats receiving 2·5 mg kg-1 day-1 survived while all rats receiving sham-treatment died. With subsequent reduction of the itraconazole dose to 0·63 mg kg-1 day-1, no survival occurred and mortality rates equalled those of the control group.

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ER -

Itraconazole treatment of experimental systemic candidiasis in Male rats

Abstract

ASJC Scopus subject areas

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