OBJECTFVE: To compare preechimptic pregnancies with and without fetal growth restriction (FGR). STUDY DESIGN: We performed a retrospective case-control study bv reviewing 252 medical records. One hundred preeclamplic women with FGR were compared to 152 preeclamptic women without FGR. Preeclampsia was denned by ACOG criteria and hyperuricemia (-45.5 mg/dL). FGR was defined bv the birth weight below the l()th percentile lor gestational age. Demographic and laboratory data, perinatal outcomes, medical, surgical, social, and family history were abstracted. Contingency table and two-tailed t test were used for statistical analyses. RESULTS: Preeclampsia with FGR had a significantly higher incidence of severe preeclampsia [OR:5.8 (2.79-11.42), p = 0.0001 j, less prenatal care (p = 0.02). less employment [OR: 2.8 (1.38-5.52). p = 0.0017J. no history of FGR [OR: 0.00 (0.00-0.66), p = 0.009], increased changes of mean arterial blood pressure (p = 0.005), higher serum uric acid (p = 0.04), hematocrit (p = 0.01), hemoglobin (p = O.OOOH), more likely to have a female fetus [OR: 2.1 (1.20-3.65), p = 0.005J, earlier gestational age at deliver) (p < 0.0001), cesarean section [OR: 2.5 (1.43-4.42), p = 0.0006J. lower Apgar scores at 1 and 5 minutes respectively (p < 0.001 and p < 0.0001). and lower birth weight (p < 0.001) than those in preeclampsia without FGR. There were no significant differences in maternal age, gravity, parity, marital status, blood type, medical, surgical, familv. preedamptic, and abortion historv, antepartal weight, height, body mass index, weight gain per week, smoking, alcohol drinking, drug use, edema, proteinuria, and serum creatiuine between these two groups. CONCLUSIONS: Preeclampsia with FGR tends to have female feiuses, increased severity of preeclampsia, hemoroncentration. no histon of FGR, less prenatal care and employment, and poor perinatal outcomes. Improving prenatal education and socioeconomic status can lead to early identification and prevention of FGR in preeclampsia.
|Original language||English (US)|
|Journal||Acta Diabetologica Latina|
|Issue number||1 PART II|
|State||Published - 1997|
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism