Is Insomnia a Risk Factor for Decreased Influenza Vaccine Response?

Daniel J. Taylor, Kimberly Kelly, Marian L. Kohut, Kai Sheng Song

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Healthy young adult college students (N = 133) with Insomnia (n = 65) or No Insomnia (n = 68) were compared on influenza serum antibody levels pre- and four weeks postvaccination. Volunteers underwent structured clinical interviews for sleep disorders to ensure insomnia diagnoses, as well as psychiatric interviews, physical examinations, and drug testing to ensure comorbid health problems were not potential confounds. There were significant time (both groups had increases in antibody levels pre- to postvaccination) and group (Insomnia group had lower HI antibody levels overall) main effects, but the time × group interaction was nonsignificant. Exploratory analyses did find significant PSQI x Time (p <.001) and Insomnia Status × Time (p =.002) interaction effects. Results indicate insomnia may be a risk factor for lowered immunity to the influenza virus.

Original languageEnglish (US)
Pages (from-to)270-287
Number of pages18
JournalBehavioral Sleep Medicine
Issue number4
StatePublished - Jul 4 2017
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Medicine (miscellaneous)
  • Psychology (miscellaneous)
  • Clinical Neurology


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