Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines

Yahui Peng; Cong Qin; Xiaobei Chen; Jianjun Li; Hao Li; Wei Wang

doi:10.1002/ajoc.201700072

Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines

Yahui Peng
, Cong Qin
, Xiaobei Chen
, Jianjun Li
, Hao Li
, Wei Wang

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

An efficient, green and atom-economical iron-catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl₃ in toluene at 110 °C for 3 h to afford the anti-Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.

Original language	English (US)
Pages (from-to)	694-697
Number of pages	4
Journal	Asian Journal of Organic Chemistry
Volume	6
Issue number	6
DOIs	https://doi.org/10.1002/ajoc.201700072
State	Published - Jun 2017
Externally published	Yes

Keywords

anti-Markovnikov
azoles
hydroamination
iron
vinylpyridines

ASJC Scopus subject areas

Organic Chemistry

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10.1002/ajoc.201700072

Cite this

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title = "Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines",

abstract = "An efficient, green and atom-economical iron-catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol \% FeCl3 in toluene at 110 °C for 3 h to afford the anti-Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.",

keywords = "anti-Markovnikov, azoles, hydroamination, iron, vinylpyridines",

author = "Yahui Peng and Cong Qin and Xiaobei Chen and Jianjun Li and Hao Li and Wei Wang",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2017",

month = jun,

doi = "10.1002/ajoc.201700072",

language = "English (US)",

volume = "6",

pages = "694--697",

journal = "Asian Journal of Organic Chemistry",

issn = "2193-5807",

publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines

AU - Peng, Yahui

AU - Qin, Cong

AU - Chen, Xiaobei

AU - Li, Jianjun

AU - Li, Hao

AU - Wang, Wei

PY - 2017/6

Y1 - 2017/6

N2 - An efficient, green and atom-economical iron-catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl3 in toluene at 110 °C for 3 h to afford the anti-Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.

AB - An efficient, green and atom-economical iron-catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl3 in toluene at 110 °C for 3 h to afford the anti-Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.

KW - anti-Markovnikov

KW - azoles

KW - hydroamination

KW - iron

KW - vinylpyridines

UR - https://www.scopus.com/pages/publications/85017472488

UR - https://www.scopus.com/pages/publications/85017472488#tab=citedBy

U2 - 10.1002/ajoc.201700072

DO - 10.1002/ajoc.201700072

M3 - Article

AN - SCOPUS:85017472488

SN - 2193-5807

VL - 6

SP - 694

EP - 697

JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

IS - 6

ER -

Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines

Abstract

Keywords

ASJC Scopus subject areas

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