Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines

Yahui Peng, Cong Qin, Xiaobei Chen, Jianjun Li, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

An efficient, green and atom-economical iron-catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl3 in toluene at 110 °C for 3 h to afford the anti-Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.

Original languageEnglish (US)
Pages (from-to)694-697
Number of pages4
JournalAsian Journal of Organic Chemistry
Volume6
Issue number6
DOIs
StatePublished - Jun 2017
Externally publishedYes

Keywords

  • anti-Markovnikov
  • azoles
  • hydroamination
  • iron
  • vinylpyridines

ASJC Scopus subject areas

  • Organic Chemistry

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