Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines

Yahui Peng; Cong Qin; Xiaobei Chen; Jianjun Li; Hao Li; Wei Wang

doi:10.1002/ajoc.201700072

Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines

Yahui Peng, Cong Qin, Xiaobei Chen, Jianjun Li, Hao Li, Wei Wang

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

An efficient, green and atom-economical iron-catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl₃ in toluene at 110 °C for 3 h to afford the anti-Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.

Original language	English (US)
Pages (from-to)	694-697
Number of pages	4
Journal	Asian Journal of Organic Chemistry
Volume	6
Issue number	6
DOIs	https://doi.org/10.1002/ajoc.201700072
State	Published - Jun 2017
Externally published	Yes

Keywords

anti-Markovnikov
azoles
hydroamination
iron
vinylpyridines

ASJC Scopus subject areas

Organic Chemistry

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10.1002/ajoc.201700072

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title = "Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines",

abstract = "An efficient, green and atom-economical iron-catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl3 in toluene at 110 °C for 3 h to afford the anti-Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.",

keywords = "anti-Markovnikov, azoles, hydroamination, iron, vinylpyridines",

author = "Yahui Peng and Cong Qin and Xiaobei Chen and Jianjun Li and Hao Li and Wei Wang",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2017",

month = jun,

doi = "10.1002/ajoc.201700072",

language = "English (US)",

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T1 - Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines

AU - Peng, Yahui

AU - Qin, Cong

AU - Chen, Xiaobei

AU - Li, Jianjun

AU - Li, Hao

AU - Wang, Wei

PY - 2017/6

Y1 - 2017/6

N2 - An efficient, green and atom-economical iron-catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl3 in toluene at 110 °C for 3 h to afford the anti-Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.

AB - An efficient, green and atom-economical iron-catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl3 in toluene at 110 °C for 3 h to afford the anti-Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.

KW - anti-Markovnikov

KW - azoles

KW - hydroamination

KW - iron

KW - vinylpyridines

UR - http://www.scopus.com/inward/record.url?scp=85017472488&partnerID=8YFLogxK

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DO - 10.1002/ajoc.201700072

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VL - 6

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EP - 697

JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

IS - 6

ER -

Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines

Abstract

Keywords

ASJC Scopus subject areas

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