TY - JOUR
T1 - IRE1/XBP1 and endoplasmic reticulum signaling — from basic to translational research for cardiovascular disease
AU - Fu, Fangyi
AU - Doroudgar, Shirin
N1 - Funding Information:
This work was supported by the German Centre for Cardiovascular Research (DZHK) Excellence Program, The University of Arizona Health Sciences Career Development Award Program , and the Translational Cardiovascular Research Center at the University of Arizona College of Medicine – Phoenix.
Publisher Copyright:
© 2022 The Authors
PY - 2022/8
Y1 - 2022/8
N2 - Most cellular protein synthesis, including synthesis of membrane-targeted and secreted proteins, which are critical for cellular and organ crosstalk, takes place at the endoplasmic reticulum (ER), placing the ER at the nexus of cellular signaling, growth, metabolism, and stress sensing. Ample evidence has established the dysregulation of protein homeostasis and the ER unfolded protein response (UPR) in cardiovascular disease. However, the mechanisms of stress sensing and signaling in the ER are incompletely defined. Recent studies have defined notable functions for the inositol-requiring kinase 1 (IRE1)/X-box- binding protein-1 (XBP1) branch of the UPR in regulation of cardiac function. This review highlights the mechanisms underlying IRE1 activation and the IRE1 interactome, which reveals unexpected functions for the UPR and summarizes our current understanding of the functions of IRE1 in cardiovascular disease.
AB - Most cellular protein synthesis, including synthesis of membrane-targeted and secreted proteins, which are critical for cellular and organ crosstalk, takes place at the endoplasmic reticulum (ER), placing the ER at the nexus of cellular signaling, growth, metabolism, and stress sensing. Ample evidence has established the dysregulation of protein homeostasis and the ER unfolded protein response (UPR) in cardiovascular disease. However, the mechanisms of stress sensing and signaling in the ER are incompletely defined. Recent studies have defined notable functions for the inositol-requiring kinase 1 (IRE1)/X-box- binding protein-1 (XBP1) branch of the UPR in regulation of cardiac function. This review highlights the mechanisms underlying IRE1 activation and the IRE1 interactome, which reveals unexpected functions for the UPR and summarizes our current understanding of the functions of IRE1 in cardiovascular disease.
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U2 - 10.1016/j.cophys.2022.100552
DO - 10.1016/j.cophys.2022.100552
M3 - Review article
AN - SCOPUS:85135400249
SN - 2468-8681
VL - 28
JO - Current Opinion in Physiology
JF - Current Opinion in Physiology
M1 - 100552
ER -