Abstract
An efficient, simple and regiospecific protocol for the synthesis of iodine-containing 2-imino(iminium)1,3- dithiolanes/dithianes/dithiepanes is reported via iodocyclization of corresponding S-(homo)propargyl dihtiocarbamates with molecular iodine. The reactions are regiospecific and only the exo-dig cyclization products were observed in all the cases. In addition, mild reaction conditions, high yields, easy purification, and using inexpensive reagents are the main advantages of this protocol.
Original language | English (US) |
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Article number | 154702 |
Journal | Tetrahedron Letters |
Volume | 128 |
DOIs | |
State | Published - Sep 19 2023 |
Keywords
- 1,3-dithiolanes
- Alkynes
- Dithiocarbamates
- Exo-dig cyclization
- Iodocyclization
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry