Invited review: Genes involved in the bovine heat stress response

R. J. Collier, J. L. Collier, R. P. Rhoads, L. H. Baumgard

    Research output: Contribution to journalArticlepeer-review

    294 Scopus citations

    Abstract

    The cellular heat stress (HS) response is one component of the acute systemic response to HS. Gene networks within and across cells and tissues respond to environmental heat loads above the thermoneutral zone with both intra- and extracellular signals that coordinate cellular and whole-animal metabolism. Activation of these systems appears to be initiated at skin surface temperatures exceeding 35°C as animals begin to store heat and rapidly increase evaporative heat loss (EVHL) mechanisms. Gene expression changes include 1) activation of heat shock transcription factor 1 (HSF1); 2) increased expression of heat shock proteins (HSP) and decreased expression and synthesis of other proteins; 3) increased glucose and amino acid oxidation and reduced fatty acid metabolism; 4) endocrine system activation of the stress response; and 5) immune system activation via extracellular secretion of HSP. If the stress persists, these gene expression changes lead to an altered physiological state referred to as "acclimation," a process largely controlled by the endocrine system. In the acclimated state, metabolism is adjusted to minimize detrimental effects of increased thermal heat load. The role of secreted HSP in feedback regulation of the immune and endocrine system has not yet been investigated. The variation in EVHL among animals and the central role that HSF1 has in coordinating thermal tolerance suggest that there is opportunity to improve thermal tolerance via gene manipulation. Determining the basis for altered energy metabolism during thermal stress will lead to opportunities for improved animal performance via altered nutritional management.

    Original languageEnglish (US)
    Pages (from-to)445-454
    Number of pages10
    JournalJournal of dairy science
    Volume91
    Issue number2
    DOIs
    StatePublished - Feb 2008

    Keywords

    • Acclimation
    • Gene expression
    • Heat stress
    • Metabolism

    ASJC Scopus subject areas

    • Food Science
    • Animal Science and Zoology
    • Genetics

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