TY - GEN
T1 - Investigation of Designs for a Stationary Adaptive Multi-Pinhole Brain SPECT Employing Flat-Square Detector Modules
AU - Kalluri, Kesava S.
AU - Auer, Benjamin
AU - Zeraatkar, Navid
AU - Richards, R. Garrett
AU - May, Micaehla
AU - Doty, Kimberly
AU - Ruiz-Gonzalez, Maria
AU - Momsen, Neil C.
AU - Kuo, Phillip H.
AU - Furenlid, Lars R.
AU - King, Michael A.
N1 - Funding Information:
Manuscript received December 11, 2020. Research reported in this publication was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Number R01 EB022521. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2020 IEEE
PY - 2020
Y1 - 2020
N2 - An adaptive-stationary-modular multi-pinhole (MPH) brain SPECT, AdaptiSPECT-C is being developed by the University of Arizona and University of Massachusetts Medical School to meet static and dynamic brain SPECT imaging needs. Salient features of the ASC include the use of adjustable pinhole apertures to dynamically adapt to imaging task needs, improved light measuring around the edge of the scintillator crystal, plus motion tracking and correction with attenuation correction enabled by usage of depth-sensing (DS)-cameras. For a target system spatial resolution of 8 mm at the focal point of the apertures, selected to enable comparison to current 2-headed commercial (2HC) SPECT imaging, we report investigation of aperture layout designs for a system with 3 rings of 18.4 cm flat square detector modules. We investigated sensitivity at the focal point in comparison to 2HC for usage of 1 versus 5 apertures per module, and variation in the extent of truncation and multiplexing of the irradiation fields by adjustment of the aperture location between the detector and focal point. For a system with one aperture per module and minor truncation we determined a sensitivity of 2.7x that of 2HC; whereas, with use of 4 oblique apertures with minor truncation and moderate multiplexing we determined the sensitivity was 4.6x, and with all 5 apertures resulting in significant multiplexing the sensitivity was 5.7x. We also determined through simulation better visualization of the rods of a Derenzo phantom, and perfusion distribution of XCAT brain phantom with the 5 pinhole design, using solely the 4 oblique pinholes. We thus believe that this design with 5 pinholes per detector module is an excellent candidate for use in construction of the AdaptiSPECT-C system.
AB - An adaptive-stationary-modular multi-pinhole (MPH) brain SPECT, AdaptiSPECT-C is being developed by the University of Arizona and University of Massachusetts Medical School to meet static and dynamic brain SPECT imaging needs. Salient features of the ASC include the use of adjustable pinhole apertures to dynamically adapt to imaging task needs, improved light measuring around the edge of the scintillator crystal, plus motion tracking and correction with attenuation correction enabled by usage of depth-sensing (DS)-cameras. For a target system spatial resolution of 8 mm at the focal point of the apertures, selected to enable comparison to current 2-headed commercial (2HC) SPECT imaging, we report investigation of aperture layout designs for a system with 3 rings of 18.4 cm flat square detector modules. We investigated sensitivity at the focal point in comparison to 2HC for usage of 1 versus 5 apertures per module, and variation in the extent of truncation and multiplexing of the irradiation fields by adjustment of the aperture location between the detector and focal point. For a system with one aperture per module and minor truncation we determined a sensitivity of 2.7x that of 2HC; whereas, with use of 4 oblique apertures with minor truncation and moderate multiplexing we determined the sensitivity was 4.6x, and with all 5 apertures resulting in significant multiplexing the sensitivity was 5.7x. We also determined through simulation better visualization of the rods of a Derenzo phantom, and perfusion distribution of XCAT brain phantom with the 5 pinhole design, using solely the 4 oblique pinholes. We thus believe that this design with 5 pinholes per detector module is an excellent candidate for use in construction of the AdaptiSPECT-C system.
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U2 - 10.1109/NSS/MIC42677.2020.9507971
DO - 10.1109/NSS/MIC42677.2020.9507971
M3 - Conference contribution
AN - SCOPUS:85124691499
T3 - 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020
BT - 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020
Y2 - 31 October 2020 through 7 November 2020
ER -