Investigation of cancer tumor biopotential in relation to tumor pH

Bruce C. Towe, Farshad Shirazi, Ali Kakavand

Research output: Contribution to journalArticlepeer-review


Biopotentials associated with adenocarcinomas in mice and hamsters were measured using a tumor-penetrating microelectrode system. Tumor ionic compositions and pH were determined by microsampling and by pH microelectrodes. We observed that the pH gradient through the tumor mass approximately follows the tumor biopotential gradient. We show that the magnitude of the observed tumor biopotentials can be explained in terms of Nernst-Planck diffusion potentials arising from tumor pH gradients.

Original languageEnglish (US)
Pages (from-to)19-36
Number of pages18
JournalElectro- and Magnetobiology
Issue number1
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Agricultural and Biological Sciences (miscellaneous)


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