@inproceedings{e9a6a899e6f347f49558e9cb475101c5,
title = "Investigation of a Monte Carlo simulation and an analytic-based approach for modeling the system response for clinical I-123 brain SPECT imaging",
abstract = "The use of accurate system response modeling has been proven to be an essential key of SPECT image reconstruction, with its usage leading to overall improvement of image quality. The aim of this work was to investigate the imaging performance using an XCAT brain perfusion phantom of two modeling strategies, one based on analytic techniques and the other one based on GATE Monte-Carlo simulation. In addition, an efficient forced detection approach to improve the overall simulation efficiency was implemented and its performance was evaluated. We demonstrated that accurate modeling of the system matrix generated by Monte-Carlo simulation for iterative reconstruction leads to superior performance compared to analytic modeling in the case of clinical 123I brain imaging. It was also shown that the use of the forced detection approach provided a quantitative and qualitative enhancement of the reconstruction.",
keywords = "Image reconstruction, Monte-Carlo simulation, SPECT I brain imaging, System response modeling, Variance reduction technique (forced detection)",
author = "Benjamin Auer and Navid Zeraatkar and {De Beenhouwer}, Jan and Kesava Kalluri and Kuo, {Philip H.} and Furenlid, {Lars R.} and King, {Michael A.}",
note = "Funding Information: Research reported in this publication was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Numbers R01 EB022521 and R01 EB022092. The content is solely the responsibility of the authors and National Institutes of Health. Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Fully3D 2019 ; Conference date: 02-06-2019 Through 06-06-2019",
year = "2019",
doi = "10.1117/12.2534881",
language = "English (US)",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Samuel Matej and Metzler, {Scott D.}",
booktitle = "15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine",
}