Investigating pulsed dye laser-blood vessel interaction with color Doppler optical coherence tomography

Jennifer Kehlet Barton; Ashley J. Welch; Joseph A. Izatt

doi:10.1364/OE.3.000251

Investigating pulsed dye laser-blood vessel interaction with color Doppler optical coherence tomography

Jennifer Kehlet Barton, Ashley J. Welch, Joseph A. Izatt

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

A non-invasive method of imaging laser irradiated blood vessels has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders. The CDOCT system used a 1280 nm center wavelength superluminescent diode. A 585 nm, 360 μs pulsed dye laser was used to irradiate hamster dorsal skin flap window preparations. Irradiation sites were imaged with CDOCT prior to, immediately after, and 24 hours after laser irradiation. The processed CDOCT signal provided an estimate of the blood flow velocity. An increase in the blood vessel backscattered signal was observed as blood or vessel walls were coagulated. A decrease in damaged blood vessel reflectivity occurred after twenty four hours.

Original language	English (US)
Pages (from-to)	251-256
Number of pages	6
Journal	Optics Express
Volume	3
Issue number	6
DOIs	https://doi.org/10.1364/OE.3.000251
State	Published - Sep 1998

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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10.1364/OE.3.000251

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title = "Investigating pulsed dye laser-blood vessel interaction with color Doppler optical coherence tomography",

abstract = "A non-invasive method of imaging laser irradiated blood vessels has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders. The CDOCT system used a 1280 nm center wavelength superluminescent diode. A 585 nm, 360 μs pulsed dye laser was used to irradiate hamster dorsal skin flap window preparations. Irradiation sites were imaged with CDOCT prior to, immediately after, and 24 hours after laser irradiation. The processed CDOCT signal provided an estimate of the blood flow velocity. An increase in the blood vessel backscattered signal was observed as blood or vessel walls were coagulated. A decrease in damaged blood vessel reflectivity occurred after twenty four hours.",

author = "Barton, {Jennifer Kehlet} and Welch, {Ashley J.} and Izatt, {Joseph A.}",

year = "1998",

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doi = "10.1364/OE.3.000251",

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N2 - A non-invasive method of imaging laser irradiated blood vessels has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders. The CDOCT system used a 1280 nm center wavelength superluminescent diode. A 585 nm, 360 μs pulsed dye laser was used to irradiate hamster dorsal skin flap window preparations. Irradiation sites were imaged with CDOCT prior to, immediately after, and 24 hours after laser irradiation. The processed CDOCT signal provided an estimate of the blood flow velocity. An increase in the blood vessel backscattered signal was observed as blood or vessel walls were coagulated. A decrease in damaged blood vessel reflectivity occurred after twenty four hours.

AB - A non-invasive method of imaging laser irradiated blood vessels has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders. The CDOCT system used a 1280 nm center wavelength superluminescent diode. A 585 nm, 360 μs pulsed dye laser was used to irradiate hamster dorsal skin flap window preparations. Irradiation sites were imaged with CDOCT prior to, immediately after, and 24 hours after laser irradiation. The processed CDOCT signal provided an estimate of the blood flow velocity. An increase in the blood vessel backscattered signal was observed as blood or vessel walls were coagulated. A decrease in damaged blood vessel reflectivity occurred after twenty four hours.

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Investigating pulsed dye laser-blood vessel interaction with color Doppler optical coherence tomography

Abstract

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