Investigating laser-blood vessel interaction with color Doppler optical coherence tomography

Jennifer Kehlet Barton, Joseph A. Izatt, Ashley J. Welch

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


A non-invasive method of imaging laser irradiated blood vessels, and of tracking the healing response, has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders such as port wine stains. The CDOCT system uses a superluminescent diode with a center wavelength of 1280 nm. Pulsed dye and KTP lasers operating at 585 and 532 nm, respectively, were used to irradiate rat and hamster dorsal skin flap window models. The window model is a chronic preparation which exposes subdermal blood vessels while maintaining a thickness of normal skin. Irradiation sites were imaged with CDOCT prior to and immediately after laser irradiation, and at intervals up to several days following irradiation. The CDOCT signal was processed to provide both magnitude and color Doppler images. The Doppler signal provides an estimate of the blood flow velocity. The response of blood vessels to radiant exposures above and below the threshold for vessel coagulation was measured. An increase in the blood vessel backscattered signal was observed as blood and vessel walls were coagulated. Changes in blood flow velocity were noted in cases where vessels constricted or flow became occluded.

Original languageEnglish (US)
Pages (from-to)102-113
Number of pages12
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1998
EventCoherence Domain Optical Methods in Biomedical Science and Clinical Applications II - San Jose, CA, United States
Duration: Jan 27 1998Jan 28 1998


  • Healing response
  • KTP laser
  • Port wine stains
  • Pulsed dye laser

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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