Introduction and Overview of Alterations in Cell Signaling

K. S. Ramos, T. J. Weber

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Cellular homeostasis involves the orchestration of complex biochemical events that ensure survival and preservation of differentiated functions. Toxic injury often alters cellular programming in ways that disrupt cellular signaling pathways and give way to altered states that may or may not be consistent with cellular functions. For simplicity, this chapter has been organized to cover the major components of signal transduction: the specific signals, the sensors, and their corresponding signaling pathways. How toxic chemicals impinge on each of these components will be discussed in general terms and reference to the specifics covered in other chapters provided when appropriate. The goal of this chapter is to describe the signaling pathways that are often affected by carcinogenic compounds, specifically tumor promoters. The basic framework of the signal transduction cascade will be investigated. In subsequent chapters, specific examples of xenobiotic alterations in signal transduction will be portrayed, as will the ultimate toxic responses of altered cell cycle control and apoptosis.

Original languageEnglish (US)
Title of host publicationComprehensive Toxicology
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages25
ISBN (Print)9780080468846
StatePublished - Jan 1 2010


  • Apoptosis
  • Calcium
  • Cell signaling
  • Cell surface receptors
  • Gap junctions
  • Growth factor receptors
  • Growth factors
  • ROS
  • Soluble receptors

ASJC Scopus subject areas

  • General Medicine


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