Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation

Meghan G. Hill; Mehtab K. Sekhon; Kathryn L. Reed; Caroline F. Anderson; Nydia D. Borjon; Jil C. Tardiff; Brent J. Barber

doi:10.1007/s00246-015-1250-1

Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation

Meghan G. Hill, Mehtab K. Sekhon, Kathryn L. Reed, Caroline F. Anderson, Nydia D. Borjon, Jil C. Tardiff, Brent J. Barber

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

There is no clear consensus on optimal management of fetuses affected by familial hypertrophic cardiomyopathy (HCM). Intrauterine treatment of the condition has not been attempted in any standardized fashion. We report the case of a fetus treated by maternal propranolol during the third trimester after septal hypertrophy and diastolic dysfunction was diagnosed on fetal echocardiogram. The pregnancy went successfully to term, and fetal septal hypertrophy was noted to improve prior to delivery.

Original language	English (US)
Pages (from-to)	1774-1777
Number of pages	4
Journal	Pediatric Cardiology
Volume	36
Issue number	8
DOIs	https://doi.org/10.1007/s00246-015-1250-1
State	Published - Dec 1 2015

Keywords

Beta myosin mutation
Fetal echocardiography
Fetal hypertrophic cardiomyopathy
Propranolol

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Cardiology and Cardiovascular Medicine

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10.1007/s00246-015-1250-1

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title = "Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation",

abstract = "There is no clear consensus on optimal management of fetuses affected by familial hypertrophic cardiomyopathy (HCM). Intrauterine treatment of the condition has not been attempted in any standardized fashion. We report the case of a fetus treated by maternal propranolol during the third trimester after septal hypertrophy and diastolic dysfunction was diagnosed on fetal echocardiogram. The pregnancy went successfully to term, and fetal septal hypertrophy was noted to improve prior to delivery.",

keywords = "Beta myosin mutation, Fetal echocardiography, Fetal hypertrophic cardiomyopathy, Propranolol",

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T1 - Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation

AU - Hill, Meghan G.

AU - Sekhon, Mehtab K.

AU - Reed, Kathryn L.

AU - Anderson, Caroline F.

AU - Borjon, Nydia D.

AU - Tardiff, Jil C.

AU - Barber, Brent J.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - There is no clear consensus on optimal management of fetuses affected by familial hypertrophic cardiomyopathy (HCM). Intrauterine treatment of the condition has not been attempted in any standardized fashion. We report the case of a fetus treated by maternal propranolol during the third trimester after septal hypertrophy and diastolic dysfunction was diagnosed on fetal echocardiogram. The pregnancy went successfully to term, and fetal septal hypertrophy was noted to improve prior to delivery.

AB - There is no clear consensus on optimal management of fetuses affected by familial hypertrophic cardiomyopathy (HCM). Intrauterine treatment of the condition has not been attempted in any standardized fashion. We report the case of a fetus treated by maternal propranolol during the third trimester after septal hypertrophy and diastolic dysfunction was diagnosed on fetal echocardiogram. The pregnancy went successfully to term, and fetal septal hypertrophy was noted to improve prior to delivery.

KW - Beta myosin mutation

KW - Fetal echocardiography

KW - Fetal hypertrophic cardiomyopathy

KW - Propranolol

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Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation

Abstract

Keywords

ASJC Scopus subject areas

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