Intrathecal morphine slows gastrointestinal transit in rats

Randy J. Koslo; Jeffry L. Vaught; Alan Cowan; Debra E. Gmerek; Frank Porreca

doi:10.1016/0014-2999(85)90303-6

Intrathecal morphine slows gastrointestinal transit in rats

Randy J. Koslo, Jeffry L. Vaught, Alan Cowan, Debra E. Gmerek, Frank Porreca

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Intrathecal (i.th.) (by direct lumbar puncture) and intraperitoneal (i.p.) administration of morphine (30-100 μg/rat) caused a dose-related inhibition of gastrointestinal transit in the rat. Pretreatment with i.th. naloxone (5 μg at -5 min) reversed the effects of i.th., but not i.p., morphine. These results suggest that the spinal cord appears to be a target site for the inhibitory effects of morphine on gastrointestinal transit in the rat.

Original language	English (US)
Pages (from-to)	243-246
Number of pages	4
Journal	European Journal of Pharmacology
Volume	119
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(85)90303-6
State	Published - Dec 17 1985

Keywords

Gastrointestinal transit
Intrathecal
Morphine
Naloxone
Rats

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(85)90303-6

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title = "Intrathecal morphine slows gastrointestinal transit in rats",

abstract = "Intrathecal (i.th.) (by direct lumbar puncture) and intraperitoneal (i.p.) administration of morphine (30-100 μg/rat) caused a dose-related inhibition of gastrointestinal transit in the rat. Pretreatment with i.th. naloxone (5 μg at -5 min) reversed the effects of i.th., but not i.p., morphine. These results suggest that the spinal cord appears to be a target site for the inhibitory effects of morphine on gastrointestinal transit in the rat.",

keywords = "Gastrointestinal transit, Intrathecal, Morphine, Naloxone, Rats",

author = "Koslo, {Randy J.} and Vaught, {Jeffry L.} and Alan Cowan and Gmerek, {Debra E.} and Frank Porreca",

note = "Funding Information: This work was supported by USPHS Grant NS-21193 (F.P.).",

year = "1985",

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doi = "10.1016/0014-2999(85)90303-6",

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T1 - Intrathecal morphine slows gastrointestinal transit in rats

AU - Koslo, Randy J.

AU - Vaught, Jeffry L.

AU - Cowan, Alan

AU - Gmerek, Debra E.

AU - Porreca, Frank

N1 - Funding Information: This work was supported by USPHS Grant NS-21193 (F.P.).

PY - 1985/12/17

Y1 - 1985/12/17

N2 - Intrathecal (i.th.) (by direct lumbar puncture) and intraperitoneal (i.p.) administration of morphine (30-100 μg/rat) caused a dose-related inhibition of gastrointestinal transit in the rat. Pretreatment with i.th. naloxone (5 μg at -5 min) reversed the effects of i.th., but not i.p., morphine. These results suggest that the spinal cord appears to be a target site for the inhibitory effects of morphine on gastrointestinal transit in the rat.

AB - Intrathecal (i.th.) (by direct lumbar puncture) and intraperitoneal (i.p.) administration of morphine (30-100 μg/rat) caused a dose-related inhibition of gastrointestinal transit in the rat. Pretreatment with i.th. naloxone (5 μg at -5 min) reversed the effects of i.th., but not i.p., morphine. These results suggest that the spinal cord appears to be a target site for the inhibitory effects of morphine on gastrointestinal transit in the rat.

KW - Gastrointestinal transit

KW - Intrathecal

KW - Morphine

KW - Naloxone

KW - Rats

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

Intrathecal morphine slows gastrointestinal transit in rats

Abstract

Keywords

ASJC Scopus subject areas

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