Intrathecal FMRFamide (Phe-Met-Arg-Phe-NH2) induces excessive grooming behavior in mice

Robert B. Raffa, Julius Heyman, Frank Porreca

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The molluscan neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) was administered intrathecally (i.t.) to mice and their behavior was monitored for 30 min. FMRFamide induced a dramatic and dose-related (5-12 μg) increase in grooming-related activities compared to saline-treated controls. The grooming behavior produced by 8 μg FMRFamide was not blocked by simultaneous i.t. administration of 10 μg of the following antagonists: atropine, phentolamine, methysergide, naloxone or spantide; peripheral administration of naloxone (3.5 mg/kg, s.c.) also failed to antagonize FMRFamide grooming. These data constitute the first report that FMRFamide produces behavioral changes in mammals.

Original languageEnglish (US)
Pages (from-to)94-98
Number of pages5
JournalNeuroscience Letters
Issue number1
StatePublished - Mar 28 1986


  • FMRFamide
  • Phe-Met-Arg-Phe-NH
  • behavior
  • grooming
  • intrathecal
  • mouse
  • neuropeptide

ASJC Scopus subject areas

  • General Neuroscience


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