Intrathecal bombesin-induced inhibition of gastrointestinal transit: requirement for an intact pituitary-adrenal axis

Randy J. Koslo; Debra E. Gmerek; Alan Cowan; Frank Porreca

doi:10.1016/0167-0115(86)90006-6

Intrathecal bombesin-induced inhibition of gastrointestinal transit: requirement for an intact pituitary-adrenal axis

Randy J. Koslo
, Debra E. Gmerek
, Alan Cowan
, Frank Porreca

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The role of the pituitary-adrenal axis in the inhibition of gastrointestinal transit caused by intrathecal administration of bombesin was examined. Bombesin (0.3-10 μg) slowed transit by this route in a dose-related manner. Either hypophysectomy or adrenalectomy prevented the inhibition of gastrointestinal transit associated with bombesin (10 μg, i.th.). The inhibitory gut effects of this peptide were not prevented in sham-operated rats. Intrathecal bombesin-induced inhibition of gastrointestinal transit is thus dependent upon an intact pituitary-adrenal axis.

Original language	English (US)
Pages (from-to)	237-242
Number of pages	6
Journal	Regulatory Peptides
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/0167-0115(86)90006-6
State	Published - May 1986

Keywords

adrenalectomy
bombesin
gastrointestinal transit
hypophysectomy
intrathecal

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Clinical Biochemistry
Cellular and Molecular Neuroscience

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10.1016/0167-0115(86)90006-6

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title = "Intrathecal bombesin-induced inhibition of gastrointestinal transit: requirement for an intact pituitary-adrenal axis",

abstract = "The role of the pituitary-adrenal axis in the inhibition of gastrointestinal transit caused by intrathecal administration of bombesin was examined. Bombesin (0.3-10 μg) slowed transit by this route in a dose-related manner. Either hypophysectomy or adrenalectomy prevented the inhibition of gastrointestinal transit associated with bombesin (10 μg, i.th.). The inhibitory gut effects of this peptide were not prevented in sham-operated rats. Intrathecal bombesin-induced inhibition of gastrointestinal transit is thus dependent upon an intact pituitary-adrenal axis.",

keywords = "adrenalectomy, bombesin, gastrointestinal transit, hypophysectomy, intrathecal",

author = "Koslo, \{Randy J.\} and Gmerek, \{Debra E.\} and Alan Cowan and Frank Porreca",

note = "Funding Information: This work was supported by USPHS Grant NS-21193 (F.P.).",

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T1 - Intrathecal bombesin-induced inhibition of gastrointestinal transit

T2 - requirement for an intact pituitary-adrenal axis

AU - Koslo, Randy J.

AU - Gmerek, Debra E.

AU - Cowan, Alan

AU - Porreca, Frank

N1 - Funding Information: This work was supported by USPHS Grant NS-21193 (F.P.).

PY - 1986/5

Y1 - 1986/5

N2 - The role of the pituitary-adrenal axis in the inhibition of gastrointestinal transit caused by intrathecal administration of bombesin was examined. Bombesin (0.3-10 μg) slowed transit by this route in a dose-related manner. Either hypophysectomy or adrenalectomy prevented the inhibition of gastrointestinal transit associated with bombesin (10 μg, i.th.). The inhibitory gut effects of this peptide were not prevented in sham-operated rats. Intrathecal bombesin-induced inhibition of gastrointestinal transit is thus dependent upon an intact pituitary-adrenal axis.

AB - The role of the pituitary-adrenal axis in the inhibition of gastrointestinal transit caused by intrathecal administration of bombesin was examined. Bombesin (0.3-10 μg) slowed transit by this route in a dose-related manner. Either hypophysectomy or adrenalectomy prevented the inhibition of gastrointestinal transit associated with bombesin (10 μg, i.th.). The inhibitory gut effects of this peptide were not prevented in sham-operated rats. Intrathecal bombesin-induced inhibition of gastrointestinal transit is thus dependent upon an intact pituitary-adrenal axis.

KW - adrenalectomy

KW - bombesin

KW - gastrointestinal transit

KW - hypophysectomy

KW - intrathecal

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IS - 3

ER -

Intrathecal bombesin-induced inhibition of gastrointestinal transit: requirement for an intact pituitary-adrenal axis

Abstract

Keywords

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