Intrasphincteric botulinum toxin type a for the diagnosis of sphincter of Oddi dysfunction: A case report

Bhaskar Banerjee, Brent Miedema, Tahira Saifuddin, John B. Marshall

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Biliary-type pain from sphincter of Oddi dysfunction is not uncommon after cholecystectomy. An increased basal pressure of sphincter of Oddi manometry establishes the diagnosis and treatment is usually by endoscopic sphincterotomy. Both procedures carry a significant complication rate. A few patients with elevated sphincter pressure do not respond to therapy; the source of their pain may be elsewhere. This case report describes the use of intrasphincteric botulinum toxin injection for the diagnosis of sphincter of Oddi dysfunction in a patient after repeated attempts at manometry had failed. This may provide a safe and easy method of determining whether sphincter of Oddi dysfunction may be the cause of biliary pain in post/cholecystectomy patients and help select patients who would benefit from subsequent sphincter ablation, without the risks of sphincter of Oddi manometry. Prospective studies are first needed.

Original languageEnglish (US)
Pages (from-to)194-196
Number of pages3
JournalSurgical Laparoscopy and Endoscopy
Issue number3
StatePublished - Jun 1999


  • Biliary pain
  • Botulinum toxin
  • Manometry
  • Sphincter of Oddi

ASJC Scopus subject areas

  • Surgery


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