Intrapulmonary localized fibrous tumor. Intraparenchymal so-called localized fibrous mesothelioma

S. A. Yousem, S. D. Flynn

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


This report describes three cases of intrapulmonary fibromas which are histologically identical to localized fibrous tumors of pleura (localized fibrous mesothelioma). Morphologically these tumors are characterized by a haphazard proliferation of cytologically bland spindle cells separated by variable amounts of wavy hyalinized collagen. Entrapped bronchiolar and alveolar epithelium is common. These spindle cells lack expression of cytoplasmic keratin, S-100 protein, desmin, and epithelial membrane antigen, but are strongly decorated for intracellular vimentin. The clinical behavior, differential diagnosis, and histogenesis of these lesions are discussed.

Original languageEnglish (US)
Pages (from-to)365-369
Number of pages5
JournalAmerican journal of clinical pathology
Issue number3
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'Intrapulmonary localized fibrous tumor. Intraparenchymal so-called localized fibrous mesothelioma'. Together they form a unique fingerprint.

Cite this