TY - JOUR
T1 - Intrapulmonary concentrations of antimicrobial agents
AU - Nix, D. E.
PY - 1998
Y1 - 1998
N2 - The delivery of antimicrobial agents to the site of infection has always been considered important. Lung infections are typically localized to the bronchial mucosa, endothelial lining fluid, and/or alveolar macrophages. Significant advances have been made in measuring antimicrobial concentrations at these sites, although some of the methods need further refinement and standardization. Relating various intrapulmonary site concentrations to efficacy or treatment failure requires further study. This article reviews the theory and methods relating to the measurement of intrapulmonary delivery of antimicrobial agents, and compares the intrapulmonary delivery of agents commonly used for the treatment of lower respiratory infections.
AB - The delivery of antimicrobial agents to the site of infection has always been considered important. Lung infections are typically localized to the bronchial mucosa, endothelial lining fluid, and/or alveolar macrophages. Significant advances have been made in measuring antimicrobial concentrations at these sites, although some of the methods need further refinement and standardization. Relating various intrapulmonary site concentrations to efficacy or treatment failure requires further study. This article reviews the theory and methods relating to the measurement of intrapulmonary delivery of antimicrobial agents, and compares the intrapulmonary delivery of agents commonly used for the treatment of lower respiratory infections.
UR - http://www.scopus.com/inward/record.url?scp=0031679439&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031679439&partnerID=8YFLogxK
U2 - 10.1016/S0891-5520(05)70202-6
DO - 10.1016/S0891-5520(05)70202-6
M3 - Article
C2 - 9779382
AN - SCOPUS:0031679439
SN - 0891-5520
VL - 12
SP - 631
EP - 646
JO - Infectious disease clinics of North America
JF - Infectious disease clinics of North America
IS - 3
ER -