INTRAPORTAL INSULIN PROTECTS FROM THE LIVER INJURY OF PORTACAVAL SHUNT IN DOGS

Thomas E. Starzl; Kendrick A. Porter; Charles W. Putnam

doi:10.1016/S0140-6736(75)92076-0

INTRAPORTAL INSULIN PROTECTS FROM THE LIVER INJURY OF PORTACAVAL SHUNT IN DOGS

Thomas E. Starzl
, Kendrick A. Porter
, Charles W. Putnam

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

4 days after portacaval shunt, the livers of normal dogs had pronounced atrophy and other structural abnormalities. These changes were greatly reduced in the left liver lobes, but not in the right, by a constant infusion to the left portal vein of insulin in non-hypoglycæmic doses. These experimental findings should have implications in clinical medicine.

Original language	English (US)
Pages (from-to)	1241-1242
Number of pages	2
Journal	The Lancet
Volume	306
Issue number	7947
DOIs	https://doi.org/10.1016/S0140-6736(75)92076-0
State	Published - Dec 20 1975
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(75)92076-0

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@article{6e54278207244285ba189a7d238c805b,

title = "INTRAPORTAL INSULIN PROTECTS FROM THE LIVER INJURY OF PORTACAVAL SHUNT IN DOGS",

abstract = "4 days after portacaval shunt, the livers of normal dogs had pronounced atrophy and other structural abnormalities. These changes were greatly reduced in the left liver lobes, but not in the right, by a constant infusion to the left portal vein of insulin in non-hypoglyc{\ae}mic doses. These experimental findings should have implications in clinical medicine.",

author = "Starzl, \{Thomas E.\} and Porter, \{Kendrick A.\} and Putnam, \{Charles W.\}",

note = "Funding Information: This work was supported by research grants from the Veterans Administration; by grants AI-AM-08898 and AM-07772 from the National Institutes of Health; by grants RR-00051 and RR-00069 from the general clinical research centers program of the Divtsion of Research Resources, National Institutes of Health; and by grant from the Medical Research Council of Great Britain.",

year = "1975",

month = dec,

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doi = "10.1016/S0140-6736(75)92076-0",

language = "English (US)",

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pages = "1241--1242",

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T1 - INTRAPORTAL INSULIN PROTECTS FROM THE LIVER INJURY OF PORTACAVAL SHUNT IN DOGS

AU - Starzl, Thomas E.

AU - Porter, Kendrick A.

AU - Putnam, Charles W.

N1 - Funding Information: This work was supported by research grants from the Veterans Administration; by grants AI-AM-08898 and AM-07772 from the National Institutes of Health; by grants RR-00051 and RR-00069 from the general clinical research centers program of the Divtsion of Research Resources, National Institutes of Health; and by grant from the Medical Research Council of Great Britain.

PY - 1975/12/20

Y1 - 1975/12/20

N2 - 4 days after portacaval shunt, the livers of normal dogs had pronounced atrophy and other structural abnormalities. These changes were greatly reduced in the left liver lobes, but not in the right, by a constant infusion to the left portal vein of insulin in non-hypoglycæmic doses. These experimental findings should have implications in clinical medicine.

AB - 4 days after portacaval shunt, the livers of normal dogs had pronounced atrophy and other structural abnormalities. These changes were greatly reduced in the left liver lobes, but not in the right, by a constant infusion to the left portal vein of insulin in non-hypoglycæmic doses. These experimental findings should have implications in clinical medicine.

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U2 - 10.1016/S0140-6736(75)92076-0

DO - 10.1016/S0140-6736(75)92076-0

M3 - Article

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AN - SCOPUS:0016825487

SN - 0140-6736

VL - 306

SP - 1241

EP - 1242

JO - The Lancet

JF - The Lancet

IS - 7947

ER -

INTRAPORTAL INSULIN PROTECTS FROM THE LIVER INJURY OF PORTACAVAL SHUNT IN DOGS

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