@article{8c8f736d40f649d9896ae1a6575dd423,
title = "Intraperitoneal chemotherapy of ovarian cancer by hydrogel depot of paclitaxel nanocrystals",
abstract = "Intraperitoneal (IP) chemotherapy is a promising post-surgical therapy of ovarian cancer, but the full potential is yet to be realized. To facilitate IP chemotherapy of ovarian cancer, we developed an in-situ crosslinkable hydrogel depot containing paclitaxel (PTX) nanocrystals (PNC). PNC suppressed SKOV3 cell proliferation more efficiently than microparticulate PTX precipitates (PPT), and the gel containing PNC (PNC-gel) showed a lower maximum tolerated dose than PPT-containing gel (PPT-gel) in mice, indicating greater dissolution and cellular uptake of PNC than PPT. A single IP administration of PNC-gel extended the survival of tumor-bearing mice significantly better than Taxol, but PPT-gel did not. These results support the advantage of PNC over PPT and demonstrate the promise of a gel depot as an IP drug delivery system.",
keywords = "Drug delivery, Hydrogel depot, Intraperitoneal chemotherapy, Nanocrystals, Ovarian cancer",
author = "Bo Sun and Taha, {Maie S.} and Benjamin Ramsey and Sandra Torregrosa-Allen and Elzey, {Bennett D.} and Yoon Yeo",
note = "Funding Information: This work was supported by NSF DMR-1056997 , NIH R01EB017791 , Purdue Research Foundation Research Grant, and the Purdue University Center for Cancer Research Small Grants Program. We also acknowledge the fellowship support from the Egyptian Government Ministry of Higher Education Missions Sector to M.S.T. The in vivo data were acquired at the Biological Evaluation Shared Resource supported by NIH P30 CA023168 . We appreciate the kind donation of the SKOV3-luc cell line from Prof. Glen S. Kwon at University of Wisconsin at Madison. We also thank Samyang Biopharm (Seoul, Korea) for the kind donation of paclitaxel and the NAL Pharmaceuticals Ltd. (Monmouth Junction, NJ, USA) for the gift support. We thank the Statistical Consulting Service in the Department of Statistic at Purdue University for the help with in vivo data analysis and Alice C. Chang for technical assistance with in vitro PTX release kinetics. Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",
year = "2016",
month = aug,
day = "10",
doi = "10.1016/j.jconrel.2016.05.056",
language = "English (US)",
volume = "235",
pages = "91--98",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",
}