Intraperitoneal chemotherapy of ovarian cancer by hydrogel depot of paclitaxel nanocrystals

Bo Sun, Maie S. Taha, Benjamin Ramsey, Sandra Torregrosa-Allen, Bennett D. Elzey, Yoon Yeo

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Intraperitoneal (IP) chemotherapy is a promising post-surgical therapy of ovarian cancer, but the full potential is yet to be realized. To facilitate IP chemotherapy of ovarian cancer, we developed an in-situ crosslinkable hydrogel depot containing paclitaxel (PTX) nanocrystals (PNC). PNC suppressed SKOV3 cell proliferation more efficiently than microparticulate PTX precipitates (PPT), and the gel containing PNC (PNC-gel) showed a lower maximum tolerated dose than PPT-containing gel (PPT-gel) in mice, indicating greater dissolution and cellular uptake of PNC than PPT. A single IP administration of PNC-gel extended the survival of tumor-bearing mice significantly better than Taxol, but PPT-gel did not. These results support the advantage of PNC over PPT and demonstrate the promise of a gel depot as an IP drug delivery system.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalJournal of Controlled Release
Volume235
DOIs
StatePublished - Aug 10 2016
Externally publishedYes

Keywords

  • Drug delivery
  • Hydrogel depot
  • Intraperitoneal chemotherapy
  • Nanocrystals
  • Ovarian cancer

ASJC Scopus subject areas

  • Pharmaceutical Science

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