Intraoperative visualization of plasmon resonant liposomes using augmented microscopy

Jeffrey R. Watson, Summer Garland, Marek Romanowski

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Plasmon resonance associated with nanoparticles of gold can enable photothermal ablation of tissues or controlled drug release with exquisite temporal and spatial control. These technologies may support many applications of precision medicine. However, clinical implementations of these technologies will require new methods of intraoperative imaging and guidance. Near-infrared laser surgery is a prime example that relies on improved image guidance. Here we set forth applications of augmented microscopy in guiding surgical procedures employing plasmon resonant gold-coated liposomes. Absorption of near-infrared laser light is the first step in activation of various diagnostic and therapeutic functions of these novel functional nanoparticles. Therefore, we demonstrate examples of near-infrared visualization of the laser beam and gold-coated liposomes. The augmented microscope proves to be a promising image guidance platform for a range of image-guided medical procedures.

Original languageEnglish (US)
Title of host publicationMolecular-Guided Surgery
Subtitle of host publicationMolecules, Devices, and Applications III
EditorsSylvain Gioux, Brian W. Pogue
ISBN (Electronic)9781510605398
StatePublished - 2017
EventMolecular-Guided Surgery: Molecules, Devices, and Applications III - San Francisco, United States
Duration: Jan 28 2017Jan 30 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMolecular-Guided Surgery: Molecules, Devices, and Applications III
Country/TerritoryUnited States
CitySan Francisco


  • Augmented microscopy
  • Fluorescence
  • Gold nanoparticles
  • Image guided surgery
  • Intraoperative imaging
  • Liposomes
  • Near-infrared laser
  • Plasmon resonant

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


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