Intraoperative imaging using intravascular contrast agent

Jeffrey R. Watson, Nikolay Martirosyan, Summer Garland, G. Michael Lemole, Marek Romanowski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Near-infrared contrast agents are becoming more frequently studied due to their advantageous characteristics, most notably the ability to work in the tissue transparency window of the electromagnetic spectrum. This produces a need for imaging technology that can be specific for both the NIR dye and the discipline. Indocyanine green is currently the primary NIR dye used in neurosurgery. Here we report on using the previously described augmented microscope for image guidance in a rat glioma resection. Luc-C6 cells were implanted in a rat in the left-frontal lobe and grown for 22 days. Surgical resection was performed by a neurosurgeon using augmented microscopy guidance with ICG contrast. Videos and images were acquired to evaluate image quality and resection margins. ICG accumulated in the tumor tissue due to enhanced permeation and retention from the compromised blood-brain-barrier. The augmented microscope was capable of guiding the rat glioma resection and highlighted tumor tissue regions via ICG signal.

Original languageEnglish (US)
Title of host publicationMolecular-Guided Surgery
Subtitle of host publicationMolecules, Devices, and Applications II
EditorsBrian W. Pogue, Sylvain Gioux
ISBN (Electronic)9781628419306
StatePublished - 2016
EventMolecular-Guided Surgery: Molecules, Devices, and Applications II - San Francisco, United States
Duration: Feb 13 2016Feb 14 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMolecular-Guided Surgery: Molecules, Devices, and Applications II
Country/TerritoryUnited States
CitySan Francisco

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


Dive into the research topics of 'Intraoperative imaging using intravascular contrast agent'. Together they form a unique fingerprint.

Cite this