@article{679aaf2c63e84d60a2f8c43b84b4a0e8,
title = "Intramolecular cyclization of imidazo[1,2-: A] pyridines via a silver mediated/palladium catalyzed C-H activation strategy",
abstract = "A C-H activation reaction was developed using imidazo[1,2-a]pyridine adducts via an AgOAc-mediated, Pd catalyzed intramolecular cyclization. The reaction was optimized and extensively explored using the Ugi/azide MCR as a tool to rapidly broaden substrate scope. Title compounds were screened against a cancer cell panel, and 6af exhibited selective, antiproliferative activity against the MCF-7 (breast cancer) cell line. This C-H activation methodology can be utilized to rapidly reach new chemical-space for drug discovery.",
author = "Debasmita Saha and Anupreet Kharbanda and Nkeseobong Essien and Lingtian Zhang and Rose Cooper and Debasish Basak and Samantha Kendrick and Brendan Frett and Li, {Hong Yu}",
note = "Funding Information: This work was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number “P20 GM109005”. H. L. was supported by the grants NIH 1R01CA194094-010 and 1R01CA197178-01A1 and UAMS start-up funding. B. F. was supported by the UAMS Seeds of Science grant, the UAMS COP Seed grant, and a grant from the American Thyroid Association (ATA/Thyca). S. K. was supported by the UAMS Seeds of Science grant and a NIH 1P20GM121293 Pilot award. Publisher Copyright: {\textcopyright} the Partner Organisations 2019.",
year = "2019",
month = jul,
day = "7",
doi = "10.1039/c9qo00389d",
language = "English (US)",
volume = "6",
pages = "2234--2239",
journal = "Organic Chemistry Frontiers",
issn = "2052-4110",
publisher = "Royal Society of Chemistry",
number = "13",
}