TY - JOUR
T1 - Intralesional Recombinant Alpha-2 Interferon for the Treatment of Patients With Condyloma Acuminatum or Verruca Plantaris
AU - Vance, J. Corwin
AU - Bart, Bruce J.
AU - Hansen, Ronald C.
AU - Reichman, Richard C.
AU - McEwen, Christopher
AU - Hatch, Kenneth D
AU - Berman, Brian
AU - Tanner, Daniel J.
PY - 1986/3
Y1 - 1986/3
N2 - • We conducted a multicenter double-blind study comparing human recombinant intralesional alpha-2 interferon (IFN) and placebo in 237 patients with the clinical diagnosis of condyloma acuminatum or verruca plantaris. A single wart on each patient was injected with 0.1 mL containing 106 IU of IFN, 105 IU of IFN, or placebo three times weekly for three weeks, and the response to treatment was followed up for 12 weeks. Among 91 of the 114 patients with condyloma acuminatum who completed the study, complete clearing of the treated wart occurred in 16 (53%) of 30 patients receiving 106 IU of IFN compared with six (19%) of 32 receiving 105 IU of IFN and four (14%) of 29 receiving placebo. In the group of 100 patients with plantar warts, there was no apparent benefit associated with interferon administration. Seven patients (3%) had treatment discontinued due to adverse reactions. Intralesional alpha-2 IFN is of benefit in the treatment of a single condyloma; its role in the treatment of multiple lesions remains to be clarified. Its role in the treatment of verruca plantaris, where no response was seen, also remains to be clarified.
AB - • We conducted a multicenter double-blind study comparing human recombinant intralesional alpha-2 interferon (IFN) and placebo in 237 patients with the clinical diagnosis of condyloma acuminatum or verruca plantaris. A single wart on each patient was injected with 0.1 mL containing 106 IU of IFN, 105 IU of IFN, or placebo three times weekly for three weeks, and the response to treatment was followed up for 12 weeks. Among 91 of the 114 patients with condyloma acuminatum who completed the study, complete clearing of the treated wart occurred in 16 (53%) of 30 patients receiving 106 IU of IFN compared with six (19%) of 32 receiving 105 IU of IFN and four (14%) of 29 receiving placebo. In the group of 100 patients with plantar warts, there was no apparent benefit associated with interferon administration. Seven patients (3%) had treatment discontinued due to adverse reactions. Intralesional alpha-2 IFN is of benefit in the treatment of a single condyloma; its role in the treatment of multiple lesions remains to be clarified. Its role in the treatment of verruca plantaris, where no response was seen, also remains to be clarified.
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U2 - 10.1001/archderm.1986.01660150050014
DO - 10.1001/archderm.1986.01660150050014
M3 - Article
C2 - 3954392
AN - SCOPUS:84944282549
SN - 0003-987X
VL - 122
SP - 272
EP - 277
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 3
ER -