Intracellular organelle-targeted non-viral gene delivery systems

Young Wook Won, Kwang Suk Lim, Yong Hee Kim

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

Gene therapy is a rapidly growing approach for the treatment of various diseases. To achieve successful gene therapy, a gene delivery system is necessary to overcome several barriers in the extracellular and intracellular spaces. Polymers, peptides, liposomes and nanoparticles developed as gene carriers have achieved efficient cellular uptake of genes. Among these carriers, cationic polymers and peptides have been further developed as intracellular organelle-targeted delivery systems. The cytoplasm, nucleus and mitochondria have been considered primary targets for gene delivery using targeting moieties or environment-responsive materials. In this review, we explore recently developed non-viral gene carriers based on reducible systems specialized to target the cytoplasm, nucleus and mitochondria.

Original languageEnglish (US)
Pages (from-to)99-109
Number of pages11
JournalJournal of Controlled Release
Volume152
Issue number1
DOIs
StatePublished - May 30 2011
Externally publishedYes

Keywords

  • Cytoplasm targeting
  • Gene therapy
  • Mitochondria targeting
  • Non-viral carrier
  • Nuclear targeting

ASJC Scopus subject areas

  • Pharmaceutical Science

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