Intracellular energy failure does not underlie hyperthermic spreading depressions in immature rat hippocampal slice

Jie Wu, Teruko Takeo, Makoto Wakui, Kevin Ellsworth, Robert S. Fisher

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Hyperthermic spreading depression (HSD) in immature rat hippocampal slices is mediated by Na+/K+-ATPase failure. Here, we test whether depleting intracellular ATP serves as a possible mechanism for HSD genesis. Results indicate that (1) pre-incubation with 3 mM creatine for 3 h failed to prevent hyperthermic spreading depression occurrence; and (2) intracellular ATP concentration doubled during experimental hyperthermia. This study suggests that HSD is not be mediated by depletion of intracellular ATP during hyperthermia.

Original languageEnglish (US)
Pages (from-to)240-243
Number of pages4
JournalBrain Research
Volume987
Issue number2
DOIs
StatePublished - Oct 17 2003
Externally publishedYes

Keywords

  • Creatine
  • Hippocampal slice
  • Hyperthermia
  • Intracellular ATP
  • Na/K-ATPase
  • Spreading depression

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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