TY - JOUR
T1 - Intracellular compartmentation of glutathione in rabbit renal proximal tubules
AU - Schnellmann, Rick G.
AU - Mandel, Lazaro J.
N1 - Funding Information:
Susan The Murdaugh authors for would their like excellent to thank technical Fontaine assistance Ewe11 and and Elizabeth Holmes for processing the manuscript. Supported by NIH grants ES-05329 and AM-28616 and a grant from the American Heart Association, North Carolina Affiliate.
PY - 1985/12/31
Y1 - 1985/12/31
N2 - The intracellular compartmentation of glutathione in rabbit renal proximal tubules was determined using digitonin, the non-ionic detergent Lubrol PX, and rapid centrifugation. Glutathione was distributed between two pools within the proximal tubules. The mitochondrial pool was the largest, containing 72 percent of the cellular glutathione while the cytoplasmic pool contained the remaining 28 percent. These results are in marked contrast to rat hepatocytes in which 85 percent of the cellular glutathione is cytoplasmic and only 15 percent is mitochondrial (1).
AB - The intracellular compartmentation of glutathione in rabbit renal proximal tubules was determined using digitonin, the non-ionic detergent Lubrol PX, and rapid centrifugation. Glutathione was distributed between two pools within the proximal tubules. The mitochondrial pool was the largest, containing 72 percent of the cellular glutathione while the cytoplasmic pool contained the remaining 28 percent. These results are in marked contrast to rat hepatocytes in which 85 percent of the cellular glutathione is cytoplasmic and only 15 percent is mitochondrial (1).
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U2 - 10.1016/0006-291X(85)91235-5
DO - 10.1016/0006-291X(85)91235-5
M3 - Article
C2 - 4084299
AN - SCOPUS:0022321345
SN - 0006-291X
VL - 133
SP - 1001
EP - 1005
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -