Interstitial pneumonitis following autologous bone marrow transplantation

John R. Wingard; Mark B. Sostrin; Huibert M. Vriesendorp; E. David Meldits; George W. Santos; Donald J. Fuller; Hayden G. Braine; Andrew M. Yeacer; William H. Burns; Rein Saral

doi:10.1097/00007890-198807000-00010

Interstitial pneumonitis following autologous bone marrow transplantation

John R. Wingard
, Mark B. Sostrin
, Huibert M. Vriesendorp
, E. David Meldits
, George W. Santos
, Donald J. Fuller
, Hayden G. Braine
, Andrew M. Yeacer
, William H. Burns
, Rein Saral

Cancer Center

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P≤0.001 for both comparisons).

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	Transplantation
Volume	46
Issue number	1
DOIs	https://doi.org/10.1097/00007890-198807000-00010
State	Published - Jul 1988

ASJC Scopus subject areas

Transplantation

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10.1097/00007890-198807000-00010

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title = "Interstitial pneumonitis following autologous bone marrow transplantation",

abstract = "Interstitial pneumonitis (IP) occurred in 20 of 143 (14\%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7\%) and CMV IP (2\%) in these marrow autograft recipients were lower than the incidences of idiopathic (19\%) and CMV IP (17\%) in comparably treated recipients of allogeneic BMT (P≤0.001 for both comparisons).",

author = "Wingard, \{John R.\} and Sostrin, \{Mark B.\} and Vriesendorp, \{Huibert M.\} and Meldits, \{E. David\} and Santos, \{George W.\} and Fuller, \{Donald J.\} and Braine, \{Hayden G.\} and Yeacer, \{Andrew M.\} and Burns, \{William H.\} and Rein Saral",

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language = "English (US)",

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TY - JOUR

T1 - Interstitial pneumonitis following autologous bone marrow transplantation

AU - Wingard, John R.

AU - Sostrin, Mark B.

AU - Vriesendorp, Huibert M.

AU - Meldits, E. David

AU - Santos, George W.

AU - Fuller, Donald J.

AU - Braine, Hayden G.

AU - Yeacer, Andrew M.

AU - Burns, William H.

AU - Saral, Rein

PY - 1988/7

Y1 - 1988/7

N2 - Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P≤0.001 for both comparisons).

AB - Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P≤0.001 for both comparisons).

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AN - SCOPUS:0023814958

SN - 0041-1337

VL - 46

SP - 61

EP - 65

JO - Transplantation

JF - Transplantation

IS - 1

ER -

Interstitial pneumonitis following autologous bone marrow transplantation

Abstract

ASJC Scopus subject areas

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