Interstitial pneumonitis following autologous bone marrow transplantation

John R. Wingard; Mark B. Sostrin; Huibert M. Vriesendorp; E. David Meldits; George W. Santos; Donald J. Fuller; Hayden G. Braine; Andrew M. Yeacer; William H. Burns; Rein Saral

doi:10.1097/00007890-198807000-00010

Interstitial pneumonitis following autologous bone marrow transplantation

John R. Wingard, Mark B. Sostrin, Huibert M. Vriesendorp, E. David Meldits, George W. Santos, Donald J. Fuller, Hayden G. Braine, Andrew M. Yeacer, William H. Burns, Rein Saral

Cancer Center

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Abstract

Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P≤0.001 for both comparisons).

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	Transplantation
Volume	46
Issue number	1
DOIs	https://doi.org/10.1097/00007890-198807000-00010
State	Published - Jul 1988

ASJC Scopus subject areas

Transplantation

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10.1097/00007890-198807000-00010

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title = "Interstitial pneumonitis following autologous bone marrow transplantation",

abstract = "Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P≤0.001 for both comparisons).",

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T1 - Interstitial pneumonitis following autologous bone marrow transplantation

AU - Wingard, John R.

AU - Sostrin, Mark B.

AU - Vriesendorp, Huibert M.

AU - Meldits, E. David

AU - Santos, George W.

AU - Fuller, Donald J.

AU - Braine, Hayden G.

AU - Yeacer, Andrew M.

AU - Burns, William H.

AU - Saral, Rein

PY - 1988/7

Y1 - 1988/7

N2 - Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P≤0.001 for both comparisons).

AB - Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P≤0.001 for both comparisons).

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Interstitial pneumonitis following autologous bone marrow transplantation

Abstract

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