Internal mammary artery and saphenous vein graft patency effects of aspirin

Steven Goldman; Jack Copeland; Thomas Moritz; William Henderson; Karen Zadina; Theron Ovitt; Karl B. Kern; Gulshan Sethi; G. V.R.K. Sharma; Shukri Khuri; Kent Richards; Fred Grover; Douglass Morrison; Michael Johnston; Elliot Chesler; Y. Sako; Ivan Pacold; Alvaro Montoya; Henry Demots; Storm Floten; James Doherty; Raymond Read; Stewart Scott; Ted Spooner; Zaki Masud; Clair Haakenson; Laurence A. Harker

Internal mammary artery and saphenous vein graft patency effects of aspirin

Steven Goldman, Jack Copeland, Thomas Moritz, William Henderson, Karen Zadina, Theron Ovitt, Karl B. Kern, Gulshan Sethi, G. V.R.K. Sharma, Shukri Khuri, Kent Richards, Fred Grover, Douglass Morrison, Michael Johnston, Elliot Chesler, Y. Sako, Ivan Pacold, Alvaro Montoya, Henry Demots, Storm FlotenJames Doherty, Raymond Read, Stewart Scott, Ted Spooner, Zaki Masud, Clair Haakenson, Laurence A. Harker

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

As part of two Department of Veterans Affairs Cooperative Trials, we obtained angiographie patency data for internal mammary artery (IMA) and saphenous vein grafts to the left anterior descending (LAD) coronary artery at 1 year after coronary artery bypass surgery. Patients received either aspirin 325 mg q.d., aspirin 325 mg t.i.d., aspirin 325 mg and dipyridamole 75 mg t.i.d., or placebo. Aspirin was initiated either 12 hours before or 6 hours after operation. Patients were stratified preoperatively for extent of disease and randomized to the therapies outlined above. There was no randomization to IMA versus saphenous vein grafts to the LAD. When the patients taking placebo were compared with those taking aspirin, there were no differences in the IMA (100.0% versus 92.1%, p=0.385) or vein graft (88.8% versus 90.4%, p=0.675) patency rates. The patency rate, irrespective of treatment, for all IMA grafts was 92.8% (220 of 237) versus 90.1% (345 of 383) for all vein grafts to the LAD (p=0.309). Thus, both the IMA and vein grafts had excellent patency rates at 1 year. Aspirin did not alter this at 1 year, and there were no differences between IMA and vein graft patency to the LAD.

Original language	English (US)
Pages (from-to)	IV237-IV242
Journal	Circulation
Volume	82
Issue number	5 SUPPL.
State	Published - 1990

Keywords

Atherosclerosis
Coronary artery bypass graft
Platelets

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

Cite this

Goldman, S., Copeland, J., Moritz, T., Henderson, W., Zadina, K., Ovitt, T., Kern, K. B., Sethi, G., Sharma, G. V. R. K., Khuri, S., Richards, K., Grover, F., Morrison, D., Johnston, M., Chesler, E., Sako, Y., Pacold, I., Montoya, A., Demots, H., ... Harker, L. A. (1990). Internal mammary artery and saphenous vein graft patency effects of aspirin. Circulation, 82(5 SUPPL.), IV237-IV242.

Goldman, S, Copeland, J, Moritz, T, Henderson, W, Zadina, K, Ovitt, T, Kern, KB, Sethi, G, Sharma, GVRK, Khuri, S, Richards, K, Grover, F, Morrison, D, Johnston, M, Chesler, E, Sako, Y, Pacold, I, Montoya, A, Demots, H, Floten, S, Doherty, J, Read, R, Scott, S, Spooner, T, Masud, Z, Haakenson, C & Harker, LA 1990, 'Internal mammary artery and saphenous vein graft patency effects of aspirin', Circulation, vol. 82, no. 5 SUPPL., pp. IV237-IV242.

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title = "Internal mammary artery and saphenous vein graft patency effects of aspirin",

abstract = "As part of two Department of Veterans Affairs Cooperative Trials, we obtained angiographie patency data for internal mammary artery (IMA) and saphenous vein grafts to the left anterior descending (LAD) coronary artery at 1 year after coronary artery bypass surgery. Patients received either aspirin 325 mg q.d., aspirin 325 mg t.i.d., aspirin 325 mg and dipyridamole 75 mg t.i.d., or placebo. Aspirin was initiated either 12 hours before or 6 hours after operation. Patients were stratified preoperatively for extent of disease and randomized to the therapies outlined above. There was no randomization to IMA versus saphenous vein grafts to the LAD. When the patients taking placebo were compared with those taking aspirin, there were no differences in the IMA (100.0% versus 92.1%, p=0.385) or vein graft (88.8% versus 90.4%, p=0.675) patency rates. The patency rate, irrespective of treatment, for all IMA grafts was 92.8% (220 of 237) versus 90.1% (345 of 383) for all vein grafts to the LAD (p=0.309). Thus, both the IMA and vein grafts had excellent patency rates at 1 year. Aspirin did not alter this at 1 year, and there were no differences between IMA and vein graft patency to the LAD.",

keywords = "Atherosclerosis, Coronary artery bypass graft, Platelets",

author = "Steven Goldman and Jack Copeland and Thomas Moritz and William Henderson and Karen Zadina and Theron Ovitt and Kern, {Karl B.} and Gulshan Sethi and Sharma, {G. V.R.K.} and Shukri Khuri and Kent Richards and Fred Grover and Douglass Morrison and Michael Johnston and Elliot Chesler and Y. Sako and Ivan Pacold and Alvaro Montoya and Henry Demots and Storm Floten and James Doherty and Raymond Read and Stewart Scott and Ted Spooner and Zaki Masud and Clair Haakenson and Harker, {Laurence A.}",

year = "1990",

language = "English (US)",

volume = "82",

pages = "IV237--IV242",

journal = "Circulation",

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T1 - Internal mammary artery and saphenous vein graft patency effects of aspirin

AU - Goldman, Steven

AU - Copeland, Jack

AU - Moritz, Thomas

AU - Henderson, William

AU - Zadina, Karen

AU - Ovitt, Theron

AU - Kern, Karl B.

AU - Sethi, Gulshan

AU - Sharma, G. V.R.K.

AU - Khuri, Shukri

AU - Richards, Kent

AU - Grover, Fred

AU - Morrison, Douglass

AU - Johnston, Michael

AU - Chesler, Elliot

AU - Sako, Y.

AU - Pacold, Ivan

AU - Montoya, Alvaro

AU - Demots, Henry

AU - Floten, Storm

AU - Doherty, James

AU - Read, Raymond

AU - Scott, Stewart

AU - Spooner, Ted

AU - Masud, Zaki

AU - Haakenson, Clair

AU - Harker, Laurence A.

PY - 1990

Y1 - 1990

N2 - As part of two Department of Veterans Affairs Cooperative Trials, we obtained angiographie patency data for internal mammary artery (IMA) and saphenous vein grafts to the left anterior descending (LAD) coronary artery at 1 year after coronary artery bypass surgery. Patients received either aspirin 325 mg q.d., aspirin 325 mg t.i.d., aspirin 325 mg and dipyridamole 75 mg t.i.d., or placebo. Aspirin was initiated either 12 hours before or 6 hours after operation. Patients were stratified preoperatively for extent of disease and randomized to the therapies outlined above. There was no randomization to IMA versus saphenous vein grafts to the LAD. When the patients taking placebo were compared with those taking aspirin, there were no differences in the IMA (100.0% versus 92.1%, p=0.385) or vein graft (88.8% versus 90.4%, p=0.675) patency rates. The patency rate, irrespective of treatment, for all IMA grafts was 92.8% (220 of 237) versus 90.1% (345 of 383) for all vein grafts to the LAD (p=0.309). Thus, both the IMA and vein grafts had excellent patency rates at 1 year. Aspirin did not alter this at 1 year, and there were no differences between IMA and vein graft patency to the LAD.

AB - As part of two Department of Veterans Affairs Cooperative Trials, we obtained angiographie patency data for internal mammary artery (IMA) and saphenous vein grafts to the left anterior descending (LAD) coronary artery at 1 year after coronary artery bypass surgery. Patients received either aspirin 325 mg q.d., aspirin 325 mg t.i.d., aspirin 325 mg and dipyridamole 75 mg t.i.d., or placebo. Aspirin was initiated either 12 hours before or 6 hours after operation. Patients were stratified preoperatively for extent of disease and randomized to the therapies outlined above. There was no randomization to IMA versus saphenous vein grafts to the LAD. When the patients taking placebo were compared with those taking aspirin, there were no differences in the IMA (100.0% versus 92.1%, p=0.385) or vein graft (88.8% versus 90.4%, p=0.675) patency rates. The patency rate, irrespective of treatment, for all IMA grafts was 92.8% (220 of 237) versus 90.1% (345 of 383) for all vein grafts to the LAD (p=0.309). Thus, both the IMA and vein grafts had excellent patency rates at 1 year. Aspirin did not alter this at 1 year, and there were no differences between IMA and vein graft patency to the LAD.

KW - Atherosclerosis

KW - Coronary artery bypass graft

KW - Platelets

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M3 - Article

C2 - 2225410

AN - SCOPUS:0025011362

SN - 0009-7322

VL - 82

SP - IV237-IV242

JO - Circulation

JF - Circulation

IS - 5 SUPPL.

ER -

Internal mammary artery and saphenous vein graft patency effects of aspirin

Abstract

Keywords

ASJC Scopus subject areas

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