Interleukin 4 dependent induction of IGE synthesis and CD23 expression by the supernatants of a human helper T cell clone

Donata Vercelli; Donald Y.M. Leung; Haifa H. Jabara; Raif S. Geha

doi:10.1159/000234761

Interleukin 4 dependent induction of IGE synthesis and CD23 expression by the supernatants of a human helper T cell clone

Donata Vercelli, Donald Y.M. Leung, Haifa H. Jabara, Raif S. Geha

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The supernatants of the human alloreactive helper T cell clone Al, which secretes interleukins (IL) 4 and 5, could induce IgE synthesis by normal peripheral blood mononuclear cells and expression of FceR2/CD23 on normal human monocytes. Both effects were IL-4 dependent, since they could be induced by recombinant IL-4 alone and were inhibited by an anti-lL-4 antibody. The activation of such clones may contribute to the high IgE production and the high percentage of circulating CD23+ monocytes observed in allergic disorders.

Original language	English (US)
Pages (from-to)	119-121
Number of pages	3
Journal	International Archives of Allergy and Immunology
Volume	88
Issue number	1-2
DOIs	https://doi.org/10.1159/000234761
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Interleukin 4 dependent induction of IGE synthesis and CD23 expression by the supernatants of a human helper T cell clone",

abstract = "The supernatants of the human alloreactive helper T cell clone Al, which secretes interleukins (IL) 4 and 5, could induce IgE synthesis by normal peripheral blood mononuclear cells and expression of FceR2/CD23 on normal human monocytes. Both effects were IL-4 dependent, since they could be induced by recombinant IL-4 alone and were inhibited by an anti-lL-4 antibody. The activation of such clones may contribute to the high IgE production and the high percentage of circulating CD23+ monocytes observed in allergic disorders.",

author = "Donata Vercelli and Leung, {Donald Y.M.} and Jabara, {Haifa H.} and Geha, {Raif S.}",

year = "1989",

doi = "10.1159/000234761",

language = "English (US)",

volume = "88",

pages = "119--121",

journal = "International Archives of Allergy and Immunology",

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T1 - Interleukin 4 dependent induction of IGE synthesis and CD23 expression by the supernatants of a human helper T cell clone

AU - Vercelli, Donata

AU - Leung, Donald Y.M.

AU - Jabara, Haifa H.

AU - Geha, Raif S.

PY - 1989

Y1 - 1989

N2 - The supernatants of the human alloreactive helper T cell clone Al, which secretes interleukins (IL) 4 and 5, could induce IgE synthesis by normal peripheral blood mononuclear cells and expression of FceR2/CD23 on normal human monocytes. Both effects were IL-4 dependent, since they could be induced by recombinant IL-4 alone and were inhibited by an anti-lL-4 antibody. The activation of such clones may contribute to the high IgE production and the high percentage of circulating CD23+ monocytes observed in allergic disorders.

AB - The supernatants of the human alloreactive helper T cell clone Al, which secretes interleukins (IL) 4 and 5, could induce IgE synthesis by normal peripheral blood mononuclear cells and expression of FceR2/CD23 on normal human monocytes. Both effects were IL-4 dependent, since they could be induced by recombinant IL-4 alone and were inhibited by an anti-lL-4 antibody. The activation of such clones may contribute to the high IgE production and the high percentage of circulating CD23+ monocytes observed in allergic disorders.

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Interleukin 4 dependent induction of IGE synthesis and CD23 expression by the supernatants of a human helper T cell clone

Abstract

ASJC Scopus subject areas

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