@article{2f9cc81a0bfb452ab53a7bbfa3130447,
title = "Interleukin-36γIs Elevated in Cervicovaginal Epithelial Cells in Women with Bacterial Vaginosis and in Vitro after Infection with Microbes Associated with Bacterial Vaginosis",
abstract = "In recent studies, the interleukin (IL)-36 cytokines were shown to be elevated in women with non-Lactobacillus-dominated vaginal microbiomes. In this study, we evaluated IL36G expression in clinical samples from women with and without bacterial vaginosis (BV) and a human 3-dimensional cervical epithelial cell model. IL36G expression was significantly elevated in cervicovaginal epithelial cells isolated from BV-positive women and corresponded with increased neutrophil counts relative to BV-negative women. In addition, specific BV-associated bacterial species as well as a polymicrobial cocktail significantly induced IL36G expression in vitro. These findings suggest that IL-36γmay exhibit an important function in the host response to BV and other sexually transmitted infections.",
keywords = "Atopobium vaginae, Gardnerella vaginalis",
author = "Gardner, {Jameson K.} and Pawe{\l} {\L}aniewski and Anna Knight and Haddad, {Lisa B.} and Alison Swaims-Kohlmeier and Herbst-Kralovetz, {Melissa M.}",
note = "Funding Information: Financial support. This work was funded by the National Institutes of Health (K23HD078153-01A1 [to L. B. H.] and 1R15AI113457-01A1 [to M. M. H. K.]), Alternatives Research and Development Foundation (to P. L. and M. M. H.-K.), and Valley Research Partnership P12 (to J. G. and M. M. H.-K.). Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2020",
month = mar,
day = "15",
doi = "10.1093/infdis/jiz514",
language = "English (US)",
volume = "221",
pages = "983--988",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",
}