Interleukin-17 inhibits Adult hippocampal neurogenesis

Qiang Liu, Wei Xin, Ping He, Dharshaun Turner, Junxiang Yin, Yan Gan, Fu Dong Shi, Jie Wu

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.

Original languageEnglish (US)
Article number7554
JournalScientific reports
Volume4
DOIs
StatePublished - Dec 19 2014
Externally publishedYes

ASJC Scopus subject areas

  • General

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