Interleukin-17 inhibits Adult hippocampal neurogenesis

Qiang Liu; Wei Xin; Ping He; Dharshaun Turner; Junxiang Yin; Yan Gan; Fu Dong Shi; Jie Wu

doi:10.1038/srep07554

Interleukin-17 inhibits Adult hippocampal neurogenesis

Qiang Liu, Wei Xin, Ping He, Dharshaun Turner, Junxiang Yin, Yan Gan, Fu Dong Shi, Jie Wu

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76 Scopus citations

Abstract

Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.

Original language	English (US)
Article number	7554
Journal	Scientific reports
Volume	4
DOIs	https://doi.org/10.1038/srep07554
State	Published - Dec 19 2014
Externally published	Yes

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title = "Interleukin-17 inhibits Adult hippocampal neurogenesis",

abstract = "Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.",

author = "Qiang Liu and Wei Xin and Ping He and Dharshaun Turner and Junxiang Yin and Yan Gan and Shi, {Fu Dong} and Jie Wu",

note = "Funding Information: This study was supported in part by National Basic Research Program of China Grant 2013CB966900, National Key-Project of Clinical Neurology, National Science Foundation of China Grant 81230028 and 81471535, Foundation of Tianjin Education Commission, National Institutes of Health Grants R01AI083294, American Heart Association Grant GRNT18970031, and Hanley family charitable trust.",

year = "2014",

month = dec,

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doi = "10.1038/srep07554",

language = "English (US)",

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journal = "Scientific reports",

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T1 - Interleukin-17 inhibits Adult hippocampal neurogenesis

AU - Liu, Qiang

AU - Xin, Wei

AU - He, Ping

AU - Turner, Dharshaun

AU - Yin, Junxiang

AU - Gan, Yan

AU - Shi, Fu Dong

AU - Wu, Jie

N1 - Funding Information: This study was supported in part by National Basic Research Program of China Grant 2013CB966900, National Key-Project of Clinical Neurology, National Science Foundation of China Grant 81230028 and 81471535, Foundation of Tianjin Education Commission, National Institutes of Health Grants R01AI083294, American Heart Association Grant GRNT18970031, and Hanley family charitable trust.

PY - 2014/12/19

Y1 - 2014/12/19

N2 - Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.

AB - Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.

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Interleukin-17 inhibits Adult hippocampal neurogenesis

Abstract

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