Research output: Chapter in Book/Report/Conference proceedingChapter


Few genes appear to be as critical for the pathogenesis of allergic inflammation in humans and animal models as interleukin (IL)-13, and even fewer appear to determine susceptibility to allergy and Asthma across human populations as consistently as IL-13. The reason behind the central role of this cytokine in disease pathogenesis probably lies in the properties of IL-13, the frequency with which the human IL-13 locus is targeted by natural genetic variation, and the functional consequences of this variation. Here we will discuss the properties of IL-13 relevant to allergic lung inflammation; we will review the results of genetic association studies investigating the relationship between IL-13 polymorphisms and allergic phenotypes; and we will propose a blueprint for functional studies of genetic variation based on the experience gained through the analysis of a common IL-13 coding variant.

Original languageEnglish (US)
Title of host publicationGenetics of Asthma and Chronic Obstructive Pulmonary Disease
PublisherCRC Press
Number of pages16
ISBN (Electronic)9781420019728
ISBN (Print)9780849369667
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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